The Influence of Cardiovascular Medications on Iron Metabolism in Patients with Heart Failure.

The etiology of anemia associated with heart failure is not fully understood, but there are data suggesting the involvement of multiple mechanisms, including various drug therapies used in patients with heart failure. Our primary objective was to evaluate the impact of beta blockers, angiotensin-converting enzyme inhibitors, and calcium-channel blockers on iron metabolism in patients with heart failure. This was a prospective observational study that included patients diagnosed with heart failure and iron deficiency (defined by ferritin <100 μg/L, or 100-300 μg/L with transferrin saturation <20%).

Imidazoline receptor antagonists idazoxan and efaroxan enhance locomotor functions in rats.

Unlabelled: Discovered in 1984, imidazoline receptors (I1, I2, I3) are located centrally and peripherally being involved in various physiologic and pathophysiologic processes in the body. Experimental and clinical investigations have suggested the interrelations between imidazoline, adrenergic, dopaminergic, glutamatergic and opioid systems, which may explain the influence of different substances acting on imidazoline receptors in cognitive disorders, behavioral disturbances and motor diseases pathways.

Aim: To investigate the effects of two imidazoline receptor antagonists on locomotor activity and endurance capacity in rats.

The effects of pregabalin on psycho-motor abilities and cognitive processes in mice.

Unlabelled: The purpose of our study was the experimental research on the effects of pregabalin in two behavioural models in mice.

Material And Methods: The experiment was carried out with white Swiss mice treated intraperitoneally as follows: Group I (Control): distilled water 0.1 ml/10 g body weight; Group II (PGB 10): 10 mg/kbw pregabalin; Group III (PGB 20): 20 mg/kbw pregabalin.

Effects of two serotoninergic agents on the behavioral manifestations in rats.

Aim: To investigate the effects of two serotonin receptor antagonists on spontaneous behavior in rats.

Material And Method: The experiment was carried out on white male Wistar rats (150-200g) divided into 3 groups of 6 animals each, treated intraperitoneally with the same volume of solution as follows: Group I (Control): saline solution 0.1 ml/10 g weight; Group II (SB-269970): SB-269970 1 mg/kbw; Group III (NAN-190): NAN-190 1 mg/kbw.

Effects of some dopamine antagonists on spatial memory performance in rats--experimental research.

Unlabelled: Dopamine is a neurotransmitter with an important role in forming long-lasting memories for some time, especially in episodic memory. Literature data show that dopamine receptor stimulation may be detrimental to spatial working memory functions in lab animals. (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride derivative--SCH-23390 is a synthetic compound that acts as a selective, high-affinity antagonist of D1 receptors.

Effects of some dopamine agents on modulation of memory processes performance in rats.

Unlabelled: Apomorphine is a potent dopamine receptor agonist which has been used as a neuro-protective agent in the treatment of Parkinson's disease. SCH-23390 is a synthetic compound that presents selective D1 dopamine receptors antagonist activity and possesses pharmacologic effects similar to standard antipsychotics.

Aim: Experimental researches on the effects of two substances acting on dopamine receptors on the cognitive processes in rats.

[Why do doctors smoke?].

Smoking prevalence is decreasing in developed countries in the last decades. Nevertheless, there is a constant increase of morbidity and mortality of smoking-related diseases (COPD, asthma, respiratory infections, cardiac diseases, cancer). Then why do doctors smoke? Because they experimented in adolescence and college and the addiction developed fast, while information about smoking risks arrived too late.