Publications by authors named "Gabriela Russo Soeiro Campos"
Photobiomodulation mitigates Bothrops jararacussu venom-induced damage in myoblast cells by enhancing myogenic factors and reducing cytokine production.
PLoS Negl Trop Dis
May 2024
Background: Photobiomodulation has exhibited promise in mitigating the local effects induced by Bothrops snakebite envenoming; however, the mechanisms underlying this protection are not yet fully understood. Herein, the effectiveness of photobiomodulation effects on regenerative response of C2C12 myoblast cells following exposure to Bothrops jararacussu venom (BjsuV), as well as the mechanisms involved was investigated.
Methodology/principal Findings: C2C12 myoblast cells were exposed to BjsuV (12.
Article Synopsis
- The study assessed the healing effects of LED light therapy using two wavelengths (635 nm and 945 nm) on the damage caused by Bothrops asper snake venom in mice.
- Treatment with LED light promptly after venom injection led to less swelling, lower white blood cell migration, and reduced pain sensitivity in the affected areas.
- Both types of LED treatment also decreased muscle damage, confirmed by lower muscle enzyme levels and histological analysis, indicating that photobiomodulation could be a promising treatment for snakebite effects.
Objective: To analyze morphological characteristics and organization of the collagen fibers of third degree burns from scalding compared to laser therapy and silver sulfadiazine, the latter considered as the gold standard.
Method: Were selected 12 animals (Rattus norvegicus) also divided into three groups (control group [CG] - untreated burns; sulfadiazine group [SG] - burns were treated with silver sulfadiazine at 1%; laser group [LG] - burns were treated with photobiomodulation). The scald burns were carried out by using PVC mold, and the material collected on the 14th day after burn was prepared for morphological and optical retardation analysis for evaluation of inflammatory infiltrates and collagen organization, respectively.