Publications by authors named "Gabriela Kniphoff da Silva Lawisch"
Article Synopsis
- * A review of literature highlighted PHI and 4Kscore as the most established serum biomarkers for PCA, while various urine tests like Progensa and ExoDXProstate also show promise in aiding diagnosis.
- * The overall search for effective biomarkers is in early stages, emphasizing the need for further research to enhance clinical application and improve PCA management.
Background: Prostate cancer (PCA) is one of the leading causes of death among men, being related to several factors, including the aging male population, like benign prostatic hyperplasia (BPH), a histopathological and hyperplastic alteration associated to prostate aging. The FASL, BCL-2 and BAX genes are involved in cell apoptosis regulation and can be related to the development of both cancer and hyperplasia. This study aimed to investigate the association of FASL - 844 (rs763110), BCL-2 -938 (rs2279115) and BAX - 248 (rs4645878) polymorphic variants in Southern Brazilian PCA and BPH patients and healthy controls.
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