Publications by authors named "Gabriela Geraldo Mendes"
Article Synopsis
- Proteins can perform crucial tasks like binding molecules, catalyzing reactions, and influencing cell behavior, making them ideal for enhancing materials in tech.
- Recent research focuses on creating active materials by fusing self-assembling proteins with functional proteins, allowing the materials to maintain their original functions.
- The review covers fusion protein design strategies, their successes and obstacles, engineering fixes for limitations, and various applications in fields like tissue engineering, drug delivery, and biosensing, as well as future development prospects.
Context-dependent HOX transcription factor function in health and disease.
Prog Mol Biol Transl Sci
June 2021
During animal development, HOX transcription factors determine the fate of developing tissues to generate diverse organs and appendages. The power of these proteins is striking: mis-expressing a HOX protein causes homeotic transformation of one body part into another. During development, HOX proteins interpret their cellular context through protein interactions, alternative splicing, and post-translational modifications to regulate cell proliferation, cell death, cell migration, cell differentiation, and angiogenesis.
View Article and Find Full Text PDFLinking changes in amino acid sequences to the evolution of transcription regulatory domains is often complicated by the low sequence complexity and high mutation rates of intrinsically disordered protein regions. For the Hox transcription factor Ultrabithorax (Ubx), conserved motifs distributed throughout the protein sequence enable direct comparison of specific protein regions, despite variations in the length and composition of the intervening sequences. In cell culture, the strength of transcription activation by Drosophila melanogaster Ubx correlates with the presence of a predicted helix within its activation domain.
View Article and Find Full Text PDFArticle Synopsis
- The development of protein-based functionalized materials is crucial for various applications due to their biocompatibility, biodegradability, and diverse mechanical properties.
- Gene fusion techniques allow the incorporation of active proteins into these materials, but traditional methods often require harsh conditions that can deactivate these proteins.
- This chapter presents a mild, cost-effective approach to create protein fibers and films in neutral pH environments, along with techniques to form fiber bundles and utilize them in cell culture, with potential applications beyond the specific protein studied.