Publications by authors named "Gabriela Ferragut"
Multitasking, or moonlighting, is the capability of some proteins to execute two or more biological functions. MultitaskProtDB-II is a database of multifunctional proteins that has been updated. In the previous version, the information contained was: NCBI and UniProt accession numbers, canonical and additional biological functions, organism, monomeric/oligomeric states, PDB codes and bibliographic references.
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- Multitasking proteins, or moonlighting proteins, can perform multiple biochemical functions, but their identification is often random, making bioinformatics crucial for prediction.
- The study explores various methods for analyzing protein sequences and structures, including remote homology searches and protein interaction data, to better understand multifunctionality.
- The findings indicate that while some programs excel at identifying primary functions, remote homology searches combined with interaction data yield the best results for detecting moonlighting functions; the MultitaskProtDB serves as a benchmark for these analyses.
Can bioinformatics help in the identification of moonlighting proteins?
Biochem Soc Trans
December 2014
Protein multitasking or moonlighting is the capability of certain proteins to execute two or more unique biological functions. This ability to perform moonlighting functions helps us to understand one of the ways used by cells to perform many complex functions with a limited number of genes. Usually, moonlighting proteins are revealed experimentally by serendipity, and the proteins described probably represent just the tip of the iceberg.
View Article and Find Full Text PDFWe have compiled MultitaskProtDB, available online at http://wallace.uab.es/multitask, to provide a repository where the many multitasking proteins found in the literature can be stored.
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