Publications by authors named "Gabriela Fernandes de Toledo"
Article Synopsis
- Oral mucosal melanomas (OMM) in dogs serve as useful models for studying similar cancers in humans, highlighting the importance of connexin proteins in cell communication and cancer progression.
- The study found that while the α-connexin carboxyl-terminal (aCT1) peptide alone did not significantly affect melanoma cell viability, the Bowman-Birk protease inhibitor (BBI) alone did decrease cell viability significantly.
- The combination of aCT1 and BBI treatment resulted in a marked reduction in cell viability, likely through enhanced expression and membrane localization of the gap junction protein connexin 43 (Cx43), suggesting a promising direction for future therapies in canine OMM.
