Publications by authors named "Gabriela F Toledo"
Oral mucosal melanoma (OMM) is a common neoplasm in canines, although it is rare in humans. Cancer cells present alterations in energetic metabolism, and the Warburg effect states that most cancer cells undergo aerobic glycolysis. This can be reversed by certain drugs, resulting in decreased cell viability and cell death.
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- Oral mucosal melanomas (OMM) in dogs serve as useful models for studying similar cancers in humans, highlighting the importance of connexin proteins in cell communication and cancer progression.
- The study found that while the α-connexin carboxyl-terminal (aCT1) peptide alone did not significantly affect melanoma cell viability, the Bowman-Birk protease inhibitor (BBI) alone did decrease cell viability significantly.
- The combination of aCT1 and BBI treatment resulted in a marked reduction in cell viability, likely through enhanced expression and membrane localization of the gap junction protein connexin 43 (Cx43), suggesting a promising direction for future therapies in canine OMM.
Sodium dichloroacetate (DCA) is a metabolic regulator used to treat diabetes. Since DCA inhibits pyruvate dehydrogenase kinase, decreasing lactic acid formation, it can reverse the Warburg effect in cancer cells, promoting apoptosis. Therefore, this study aimed to investigate the potential of DCA as a drug repurposing candidate for the treatment of melanoma.
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