[Effects of 12 sessions of high intensity intermittent training and nutrition counseling on body fat in obese and overweight participants].

Background: The search of efficient exercise alternatives to treat obesity is worthwhile.

Aim: To demonstrate the effect of high intensity intermittent exercise on body fat reduction in overweight and obese subjects.

Material And Methods: A group of 65 overweight and obese adult subjects (25 men), aged 18-65 years, participated during 12 sessions in a high intensity physical exercise program, 3 days/week.

Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation.

Purpose: Previous gene expression studies have shown that fibroblast growth factor receptor 3 (FGFR3) is overexpressed in early stages of bladder cancer. To study the potential use of therapeutic antibodies against FGFR3, we have produced a collection of human single-chain Fv (scFv) antibody fragments by using phage display libraries.

Experimental Design: Two "naïve" semi-synthetic human scFv libraries were used to select antibodies against the extracellular domain of FGFR3alpha(IIIc).