Publications by authors named "Gabriela Carmelinda Martins dos Santos"
Article Synopsis
- Fipronil (FIP) is a topical ectoparasiticide that shows promise for oral administration due to risks of human exposure and environmental damage from existing formulations.
- Evidence from studies demonstrated that FIP is effective against fleas and ticks in dogs, with optimal dosages providing near-complete efficacy at 48 hours post-treatment.
- The pharmacokinetics of FIP indicated rapid absorption and metabolism but slower elimination, suggesting its potential as a safer and effective oral treatment option that aligns with the One Health concept for better health outcomes for animals, humans, and the environment.
Zoonoses are major causes of morbidity and mortality worldwide. Among them, Brazilian Spotted Fever (BSF) is an important one that occurs in some regions of South America and can be transmitted by the "star tick" Amblyomma sculptum. Application of acaricides against the larval stage is important as strategy of population control.
View Article and Find Full Text PDFIncreased human-pet interactions have led to concerns related to the prevention and treatment of ectoparasite infestations. Fipronil (FIP) is a widely used ectoparasiticide in veterinary medicine available for topical administration; however, its use may cause damage to the owners and the environment. The aim of the study was to develop immediate-release tablets of FIP, as well as to determine its pharmacokinetic properties after oral administration in beagle dogs.
View Article and Find Full Text PDFLophanthera lactescens is a medicinal plant commonly used in traditional medicine to relieve fever and pain in inflammatory processes. In the present study, the in vivo antinociceptive and anti-inflammatory effects of the methanolic extract from L. lactescens have been investigated.
View Article and Find Full Text PDFThe leaves of Myrcia ovata, popularly known as "laranjinha do mato", are frequently used as an infusion in folk medicine. The essential oil obtained from these leaves is rich in citral, a mixture of neral and geranial isomers, known for its analgesic effect. Male Swiss mice (20-22 g) were tested in models of acute pain (acetic acid-induced abdominal writhing, tail flick, and formalin tests) and acute inflammation (paw oedema and air pouch tests) as well as in a model for evaluation of spontaneous motor performance (open-field test).
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