Upregulation of the and genes and miRNAs involved in DNA damage response and repair in gastric cancer.

Gastric cancer remains one of the leading causes of cancer-related death worldwide, and most of the cases are associated with infection. This bacterium promotes the production of reactive oxygen species (ROS), which cause DNA damage in gastric epithelial cells. In this study, we evaluated the expression of important genes involved in the recognition of DNA damage (, , and ) and ROS-induced damage repair () and the expression of some miRNAs (miR-15a, miR-21, miR-24, miR-421 and miR-605) that target genes involved in the DNA damage response (DDR) in 31 fresh tissues of gastric cancer.