Disambiguating the optic nerve from the surrounding cerebrospinal fluid: Application to MS-related atrophy.

Purpose: Our goal is to develop an accurate, automated tool to characterize the optic nerve (ON) and cerebrospinal fluid (CSF) to better understand ON changes in disease.

Methods: Multi-atlas segmentation is used to localize the ON and sheath on T2-weighted MRI (0.6 mm(3) resolution).