Publications by authors named "Gabriela A Berg"
Article Synopsis
- The study explores how dyslipidemia, specifically oxidized LDL (OxLDL), affects the proliferation of prostatic stromal cells and the release of extracellular vesicles (EVs), which are linked to Benign Prostatic Hyperplasia (BPH).
- Mice were given a high-fat diet and human prostatic stromal cells were exposed to OxLDL, revealing that dyslipidemic conditions promote increased cell growth and the secretion of EVs that further stimulate this growth.
- Treatment with metformin was found to significantly reduce OxLDL-induced cell proliferation, suggesting it could be a potential therapeutic option for managing BPH by targeting the underlying mechanisms associated with dyslipidemia.
Background: The prevalence of obesity (OB), overweight (OW), and metabolic syndrome (MS) has increased worldwide. That imposes a substantial risk for type 2 diabetes and premature cardiovascular disease. However, to date no unified criteria exist to asses risk or outcomes in children and adolescents.
View Article and Find Full Text PDFRemnant lipoproteins (RLPs) are the lipolytic product of triglycerides transported by very low density lipoproteins (VLDL) of hepatic and intestinal origin and intestinal chylomicrons. Lipoprotein lipase activity hydrolyse triglycerides in several steps, producing heterogeneous particles. Fasting plasma concentration in normolipidemic subjects is low, but it increases in post-prandial states.
View Article and Find Full Text PDFBackground And Aims: Many studies suggest that the different steps of the atherosclerotic process may be mediated by metalloproteases (MMPs). MMP-9 and MMP-2, which are highly expressed in the vulnerable regions of the atherosclerotic plaques, have been suggested to be causally involved in plaque rupture. In another manner linked with LDL, lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) hydrolyzes phospholipids generating proinflammatory and proatherogenic products.
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