Publications by authors named "Gabriel Zherong Yan"
Singapore tuberculosis (TB) clinical management guidelines 2024: A modified Delphi adaptation of international guidelines for drug-susceptible TB infection and pulmonary disease.
Ann Acad Med Singap
March 2024
Introduction: Tuberculosis (TB) remains endemic in Singapore. Singapore's clinical practice guidelines for the management of tuberculosis were first published in 2016. Since then, there have been major new advances in the clinical management of TB, ranging from diagnostics to new drugs and treatment regimens.
View Article and Find Full Text PDFStudy protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO).
BMC Infect Dis
January 2024
Article Synopsis
- Community-acquired respiratory infections, particularly pneumonia, pose a significant global health challenge, and their specific causes are not well understood.
- The RESPIRO study is a prospective observational cohort study in Singapore that seeks to identify the causes of moderate-to-severe pneumonia in adults and explore factors affecting different pathogens.
- Conducted at three major hospitals, the study involves collecting clinical data and biological samples from hospitalized patients to create a detailed database and biorepository, which will improve understanding of the epidemiology and outcomes of these infections.
Article Synopsis
- This study explored using whole-genome sequencing (WGS) to predict antifungal resistance in Candida tropicalis strains resistant to anidulafungin.
- Next-generation sequencing was carried out on three resistant isolates, revealing specific mutations linked to their resistance.
- Results suggest that WGS can potentially be used to inform treatment decisions for patients with candidaemia as the technology advances.
The Cepheid Xpert® Norovirus kit automates sample processing, nucleic acid extraction, and real-time reverse transcription polymerase chain reactions (RT-PCRs) to detect norovirus genogroups I (GI) and II (GII). Eighty-five stool samples collected between February 2015 and May 2017 were used to compare the performance of a user-modified Xpert assay against a clinically validated laboratory-developed test (LDT). Of the 85 samples, 54 were previously archived in -80°C freezer.
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