Novel anti-virulence compounds disrupt exotoxin expression in MRSA.

Hemolysins are lytic exotoxins expressed in most strains of , but hemolytic activity varies between strains. We have previously reported several novel anti-virulence compounds that disrupt the transcriptome, including hemolysin gene expression. This report delves further into our two lead compounds, loratadine and a structurally related brominated carbazole, and their effects on hemolysin production in methicillin-resistant (MRSA).

Novel Anti-virulence Compounds Disrupt Exotoxin Expression in MRSA.

Hemolysins are lytic exotoxins expressed in most strains of , but hemolytic activity varies between strains. We have previously reported several novel anti-virulence compounds that disrupt the transcriptome, including hemolysin gene expression. This report delves further into our two lead compounds, loratadine and a structurally related brominated carbazole, and their effects on hemolysin production in MRSA.

Loratadine Combats Methicillin-Resistant by Modulating Virulence, Antibiotic Resistance, and Biofilm Genes.

Methicillin-resistant (MRSA) has evolved to become resistant to multiple classes of antibiotics. New antibiotics are costly to develop and deploy, and they have a limited effective lifespan. Antibiotic adjuvants are molecules that potentiate existing antibiotics through nontoxic mechanisms.