Publications by authors named "Gabriel Verly"
Article Synopsis
- Intracranial aneurysms are rare in children, making up less than 5% of cases, and their unique shape poses challenges for treatment, particularly with the growing use of flow-diverter devices like the Pipeline Embolization Device (PED).
- A systematic review and meta-analysis were conducted using data from Medline, Embase, and Web of Science, focusing on studies with at least three pediatric patients to evaluate outcomes such as occlusion rates, complications, and mortality.
- The analysis included 80 patients and showed a high immediate occlusion rate of 90%, favorable clinical outcomes in 92% of cases, and a low complication rate of 3%, indicating that flow-diverter
Aim: To evaluate the usage and the effectiveness of LVIS Jr device technology in managing wide-neck intracranial aneurysms.
Material And Methods: PubMed, Embase, and Web of Science databases, comprising studies with outcomes related to LVIS Jr use in wide-neck intracranial aneurysms were searched systematically. Data was extracted from the selected articles and subjected to statistical analysis.
Article Synopsis
- WHO Grade 2 meningiomas pose diagnostic and management challenges, with surgery (particularly gross total resection) being essential, often followed by adjuvant radiotherapy, though the effectiveness of this combination is still under investigation.
- A systematic review analyzed data from 23 studies involving 3,822 patients, comparing outcomes of gross total resection alone versus with adjuvant radiotherapy and found that the combination significantly improved progression-free survival, though overall survival needs more research to determine if there's a substantial benefit.
- The study concludes that adjuvant radiotherapy enhances progression-free survival for WHO Grade 2 meningiomas, and future treatments should consider molecular characteristics to improve management strategies.
Introduction: Familial Cerebral Cavernous Malformations (fCCMs) are rare, hereditary conditions characterized by multiple central nervous system lesions. Despite their rarity, CCMs can cause significant clinical challenges when symptomatic, manifesting as seizure and symptomatic hemorrhage (CASH). Guidelines suggest neurosurgical intervention for symptomatic or previously symptomatic lesions, while conservative management is recommended for new-onset epilepsy.
View Article and Find Full Text PDFEarly and long-term outcome of surgical versus conservative management for intracranial cerebral cavernous malformation: Meta-analysis of reconstructed time-to-event data.
Clin Neurol Neurosurg
November 2024
Article Synopsis
- The meta-analysis explores the effectiveness of surgical intervention versus conservative management for symptomatic cerebral cavernous malformations (CCMs), tackling the challenges of uncertain clinical management due to limited trial data.
- Results indicate that while surgical intervention might lead to more events (neurological deficits or bleeding) in the long run, observational management showed a longer mean time before these events occurred.
- The study concludes that observational management could offer better long-term outcomes and emphasizes the necessity for more research, including randomized controlled trials, to improve treatment approaches for CCMs.
Article Synopsis
- Stereotactic Brachytherapy Iodine-125 (SBT I-125) is a treatment studied for low-grade gliomas, but the results raise concerns about its safety and effectiveness.
- A review of 20 studies showed that about 10% of patients had complications and 33% faced mortality, even though some patients were able to remain progression-free for 5 or 10 years.
- The researchers suggest that more long-term studies and better research methods are needed to understand the true effects of this treatment.
Open cell stents (OC) and closed cell stents (CC) each offer unique advantages and potential drawbacks in the context of idiopathic intracranial hypertension (IIH) treatment. We aim to investigate the safety and efficacy of using OC and CC for IIH. We conducted a systematic review in PubMed, Embase, and Cochrane Library databases following the PRISMA guidelines.
View Article and Find Full Text PDFBackground: Some centers utilize ventriculopleural shunt (VPLS) for treating hydrocephalus when conventional approaches are not feasible. Nonetheless, the literature regarding this approach is scarce.
Purpose: Evaluate the outcomes of VPLS through a single-arm meta-analysis.
Good clinical outcomes and the necessity of CSF drainage in patients undergoing simultaneous biopsy and endoscopic third ventriculostomy in the region of pineal tumors: A systematic review and meta-analysis.
J Clin Neurosci
August 2024
Introduction: Due to their delicate and deep-seated location, tumors in the pineal region of the brain pose exceptional challenges in neurosurgical management. Highly precise procedures have become crucial to address these complexities, such as the simultaneous performance of biopsy and endoscopic third ventriculostomy (ETV). Our aim was to assess the feasibility, safety, and efficacy of simultaneous biopsy and ETV for treating patients with pineal region tumors.
View Article and Find Full Text PDFMultiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). Neuropathic pain in MS is a debilitating symptom that significantly impairs the quality of life for a substantial proportion of MS patients. Neuropathic pain in MS stems primarily from demyelination, axonal loss, CNS inflammation, and direct damage to the myelin sheath, leading to pain manifestations such as ongoing extremity pain, Lhermitte's phenomenon, and trigeminal neuralgia (TN).
View Article and Find Full Text PDFEfficacy and safety of microvascular decompression with or without partial sensory rhizotomy: a comprehensive meta-analysis and systematic review in treating trigeminal neuralgia.
Neurosurg Rev
May 2024
Classical trigeminal neuralgia (TN), caused by vascular compression of the nerve root, is a severe cause of pain with a considerable impact on a patient's quality of life. While microvascular decompression (MVD) has lower recurrence rates when compared with partial sensory rhizotomy (PSR) alone, refractoriness can still be as high as 47%. We aimed to assess the efficacy and safety profile of MVD + PSR when compared to standalone MVD for TN.
View Article and Find Full Text PDFArticle Synopsis
- Cavernomas are genetic vascular lesions located in the central nervous system that may require alternative treatment options, like Gamma Knife stereotactic radiosurgery (GKSRS), when found in critical areas where surgery is not advisable.
- A systematic review and meta-analysis of seven studies involving 1,071 patients revealed that GKSRS had an 89.8% events-free rate at two years and 71.3% at ten years following treatment.
- The findings suggest that GKSRS is a promising alternative for managing symptomatic cavernomas, but further research is necessary to strengthen these conclusions.
The treatment for peripheral nerve sheath tumors (PNSTs) is based on surgical excision and the primary goal is to improve symptoms whilst preserving neurological function. In order to improve this technique, surgeons may use sodium fluorescein (SF) to help visualize the neoplasm and, consequently, facilitate its removal. Aiming to assess the efficacy of this emerging surgical strategy, we conducted a systematic review and single-arm meta-analysis.
View Article and Find Full Text PDFBackground: High-grade gliomas (HGGs) present a challenge in neuro-oncology, often necessitating surgical resection for optimal management. Ultrasound holds promise in achieving better gross total resection (GTR) and improving outcomes. This meta-analysis systematically evaluates literature providing robust evidence on the use of intraoperative ultrasonography (iUSG) in HGG resection.
View Article and Find Full Text PDFBackground: Glioblastoma (GBM) is an aggressive tumor known for its poor prognosis. Despite extensive research into its molecular and clinical aspects, the current management strategies have shown limited efficacy in improving survival rate. Despite some preclinical studies exploring the combination of temozolomide (TMZ) with biguanides such as metformin (MET) and others, the potential benefits of this combination remain uncertain.
View Article and Find Full Text PDFBackground: The impact of traumatic brain injury (TBI) on the pediatric population is profound. The aim of this study is to unveil the state of the evidence concerning acute neurosurgical intervention, hospitalizations after injury, and neuroimaging in isolated skull fractures (ISF).
Materials And Methods: This systematic review was conducted in accordance with PRISMA guidelines.
Presurgical embolization (PE) has emerged as an interesting strategy to help turn brain tumor resection more amenable. This study aims to systematically review the safety and effectiveness of Onyx™ PE in meningioma resection. We followed Cochrane Collaboration and PRISMA for systematic review and meta-analysis, querying PUBMED, Cochrane Library, Web of Science, and Embase databases.
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