Polypharmacology-Driven Discovery and Design of Highly Selective, Dual and Multitargeting Inhibitors of - A Review.

The increasing demand for novel antitubercular agents has been the main 'force' of many TB research efforts due to the uncontrolled growing number of drug-resistant strains of in the clinical setting. Many strategies have been employed to address the drug-resistant issue, including a trend that is gaining attention, which is the design and discovery of inhibitors that are either dual- or multitargeting. The multiple-target design concept is not new in medicinal chemistry.