Publications by authors named "Gabriel Matherat"
Article Synopsis
- Macrophage populations in the Yolk Sac develop from distinct progenitor waves before hematopoietic stem cells form, contributing to primitive macrophages in embryonic organs.
- Lyl-1, a transcription factor, is shown to be crucial for the development and differentiation of these macrophage progenitors, with its deficiency leading to disruptions in gene regulation related to embryonic patterns and neurodevelopment.
- The lack of Lyl-1 results in an initial increase of primitive macrophage progenitors, followed by compromised development of mature macrophages and microglia in the brain during crucial stages of early growth.
The gene CXXC5, encoding a Retinoid-Inducible Nuclear Factor (RINF), is located within a region at 5q31.2 commonly deleted in myelodysplastic syndrome (MDS) and adult acute myeloid leukemia (AML). RINF may act as an epigenetic regulator and has been proposed as a tumor suppressor in hematopoietic malignancies.
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