The Dc(G48)e(s) haplotype is frequent among the Dce haplotypes within a white population.

Background: The absence of hybrid Rhesus boxes denotes an RHD homozygous status and helps to detect the presence of Dce haplotypes instead of dce. RHCE exon 1 C48, characteristic of RHC alleles, and RHCE exon 5 G733, responsible for VS antigenicity, have been noted in many RHce alleles but it was not clearly established whether they occurred in the same allele and/or cosegregate together with RHD.

Study Design And Methods: Samples from 148 white trios (father, mother, and child) were studied.