Publications by authors named "Gabriel M C Guimaraes"
Background: Severe cases of coronavirus disease 2019 (COVID-19) have increased risk for acute kidney injury (AKI). The exacerbation of the immune response seems to contribute to AKI development, but the immunopathological process is not completely understood.
Objectives: To analyze levels of circulant immune mediators in COVID-19 patients evolving with or without AKI.
Increased Indoleamine 2,3-Dioxygenase 1 (IDO-1) Activity and Inflammatory Responses during Chikungunya Virus Infection.
Pathogens
April 2022
Chikungunya virus (CHIKV) infection causes intense cytokine/chemokine inflammatory responses and debilitating joint pain. Indoleamine2,3-dioxygenase 1 (IDO-1) is an enzyme that initiates the tryptophan degradation that is important in initial host innate immune defense against infectious pathogens. Besides that, IDO-1 activation acts as a regulatory mechanism to prevent overactive host immune responses.
View Article and Find Full Text PDFThe co-circulation of chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV) in Rio de Janeiro (RJ), Brazil, caused a challenging triple epidemic, as they share similar clinical signs and symptoms and geographical distribution. Here, we aimed to investigate the clinical and laboratorial aspects of chikungunya suspected cases assisted in RJ during the 2018 outbreak, focusing on the differential diagnosis with dengue and zika. All suspected cases were submitted to molecular and/or serological differential diagnostic approaches to arboviruses.
View Article and Find Full Text PDFArticle Synopsis
- Chikungunya virus (CHIKV) causes severe joint pain and currently has no specific treatment or vaccine, prompting the need for reliable serological markers for better patient management.
- The study investigated serum levels of the protein HMGB1 in CHIKV-infected patients, finding significantly higher levels compared to healthy controls, which remained elevated during the acute phase of the illness.
- Results suggest that HMGB1 could serve as a useful biomarker for diagnosing and managing chikungunya fever, linking its levels to the severity of the infection.
Introduction: Some COVID-19 patients have higher mortality and the responsible factors for this unfavorable outcome is still not well understood.
Objective: To study the association between ferritin levels at admission, representing an inflammatory state, and hospital mortality in COVID-19 patients.
Methods: From May through July 2020, SARS-CoV-2 positive patients with moderate to severe clinical symptoms were evaluated at admission, regarding clinical and laboratory data on renal and hepatic function, hematologic parameters, cytomegalovirus co-infection, and acute phase proteins.