Post-operative small pelvic field radiation therapy in patients with intermediate risk early stage cervix cancer: a safe and efficient treatment modality.

Background: The treatment of early stage cervical cancer has different therapeutic options. Adjuvant external beam radiotherapy for surgically treated intermediate risk cervical cancer patients has shown acceptable oncological outcomes with a low incidence of toxicity. The aim of this study was to analyze the oncological outcomes and safety of adjuvant small pelvic field radiotherapy in surgically treated stage IB1-2 cervical cancer patients who met the Sedlis intermediate-risk criteria.

Main concepts on bioequivalence and biosimilarity in the Chilean legislation, and current controversies on drug interchangeability.

Medicines are an economic good and a fundamental component of public and private spending and health decision-making. Assurance of their quality, efficiency and safety is essential. However, the variety of products on the Chilean market, including innovative and generic productsthe latter accounted for by many products that are certified as bioequivalent while others are notresults in a potentially confusing scenario for consumers and health providers.

General concepts in biostatistics and clinical epidemiology: observational studies with cohort design.

Cohort studies evaluate the relationship between exposure to a specific event or phenomenon and the occurrence of an associated out-come of interest (or lack thereof). This methodological design has been widely used in certain areas of medicine, such as the study of cardiovascular risk factors and the effects of ionizing radiation in humans. It is a useful study design, especially for research involving low-occurrence exposures, because it can be easily adapted to various contexts.