Publications by authors named "Gabriel La Rocca"
Background: Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic hematological disorders characterized by the overproduction of one or more mature myeloid blood cell lineages. Classical Ph-MPN are polycythemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF).
Aim: To assess the epidemiological, clinical and diagnostic characteristics of Ph-MPN in Chile.
Article Synopsis
- Philadelphia-negative myeloproliferative neoplasms (Ph-MPN) are chronic blood disorders marked by excessive production of myeloid blood cells, with major types being polycythemia vera (PV), essential thrombocytopenia (ET), and primary myelofibrosis (PMF).
- A study in Chile reviewed the medical records of 462 patients referred for MPN from 2012 to 2017, finding that ET was the most common type, with a reported incidence of 1.5 cases per 100,000 people.
- Despite extensive testing for the JAK2 V617F mutation, only 30% of patients underwent a bone marrow biopsy, and overall survival was 87
Article Synopsis
- The study examined the clinical and survival characteristics of transplant-eligible multiple myeloma patients in Latin America, focusing on the differences between public and private healthcare systems.
- It included data from 1293 patients diagnosed from 2010 to 2018, highlighting significant disparities in outcomes and survival rates between those treated in public versus private institutions.
- The findings suggest that late diagnosis and limited access to effective treatments in public facilities contribute to poorer survival rates, while patients receiving modern therapies and autologous stem cell transplants have survival rates comparable to international standards.
Background The treatment of choice of newly diagnosed multiple myeloma (NDMM) is an induction with proteasome inhibitors followed autologous stem cell transplantation (HSCT). Since 2013, the treatment of these patients in the public system is based on CTD (cyclophosphamide, thalidomide, and dexamethasone). Aim To evaluate the response rates achieved with CTD, and the results of HSCT in patients with NDMM in the public setting.
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