Publications by authors named "Gabriel Henrique Costa da Silva"
Oral formulation of Wnt inhibitor complex reduces inflammation and fibrosis in intraperitoneal implants in vivo.
Ana Luíza de Castro Santos Natália Jordana Alves da Silva Celso Tarso Rodrigues Viana Letícia Cristine Cardoso Dos Santos Gabriel Henrique Costa da Silva Walison Nunes da Silva
Drug Deliv Transl Res
May 2023
Article Synopsis
- The study explores the challenges of using implantable biomaterials, which can trigger inflammation and fibrosis, leading to their eventual failure and removal.
- It focuses on the Wnt signaling pathway's role in the healing process and tests a Wnt inhibitor (CD:LGK974) to mitigate these adverse effects.
- Results showed that CD:LGK974 effectively reduced inflammation, collagen production, and blood vessel formation around the implants, suggesting it could improve the longevity and functionality of biomaterials in clinical settings.