Publications by authors named "Gabriel Gomes Silva"

Given the complexity of the behavior of mining tailings dams built by the technique of hydraulic embankments and the recurring dam ruptures globally, especially in Brazil, ensuring enhanced safety through advanced disposal techniques becomes crucial. While the co-disposal method has been extensively explored for various mineral substances, a notable gap exists in the literature concerning its application specifically to tailings and waste rock generated from phosphate mining operations. This study aims to identify the optimal ratio for a mining tailings and waste rock mixture and evaluate its mechanical behavior in comparison to individual materials.

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Odontomas and ameloblastic fibro-odontomas (AFOs) are the result of a developmental anomaly of odontogenic tissues. A literature review of proteins immunoexpressed in odontomas and AFOs was conducted in order to determine which proteins are involved in the pathogenesis of these lesions. AFO was changed to early odontoma in the 2017 WHO classification and will also be discussed in this article.

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Article Synopsis
  • The study assessed the effects of different naphthoquinones on the growth of Trypanosoma cruzi epimastigotes and the viability of VERO cells, finding that β-lapachone and Epoxy-α-lap exhibited high trypanocidal activity.
  • Results showed that these compounds target different types of proteinases in T. cruzi; β-lapachone inhibits cysteine-proteinases, while Epoxy-α-lap inhibits serine-proteinases, indicating distinct mechanisms of action.
  • The findings suggest the potential for developing new treatments for Chagas disease by utilizing β-lapachone and Epoxy-α-lap as models for designing protease inhibitors.
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Cysteine proteinases are an important virulence factor in Leishmania parasites. In this study we analyzed the cysteine proteinase expression of infective Leishmania (Viannia) braziliensis promastigotes, examining the expression induced by successive in vitro passages in culture. We observed that this parasite presents a decrease in its virulence over BALB/c macrophages, after successive passages in culture, but still they present proteinase activity, being capable of hydrolyzing the substrate pGlu-Phe-Leu-p Nitroanilide at pH 7.

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