Publications by authors named "Gabriel Fernandes de Andrade"
Background: Tuberculosis (TB) is a serious disease that still affects humanity, despite being old, caused by the bacterium . The emergence of drug-resistant strains has alarmed governments and international organizations, such as the World Health Organization (WHO). The need for research on new drugs that are effective in a shorter treatment time and active against resistant strains still persists.
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- Alveolar echinococcosis (AE) is a disease caused by the fox tapeworm E. multilocularis, primarily affecting the liver of humans and various mammals, highlighting the need for better treatments due to limitations of current drug options.
- Mefloquine (MEF), an antimalarial drug, shows some effectiveness against E. multilocularis but is not parasiticidal and can cause severe side effects, necessitating research into its mechanisms and how to enhance its therapeutic potential.
- The study involved analyzing 14 MEF derivatives to identify effective compounds and revealed 1,681 proteins that interact with MEF; specific pathways related to energy metabolism and stress responses were highlighted, with ferritin identified
The development of new drugs requires a lot of time and high financial investments. It involves a research network in which there is the participation of several researchers from different areas. For a new drug to reach the market, thousands of substances must be evaluated.
View Article and Find Full Text PDFAntibacterial activity of new substituted 4-N-alkylated-2-trifluoromethyl-quinoline analogues against sensitive and resistant Mycobacterium tuberculosis strains.
Eur J Pharm Sci
February 2021
Objectives: The emergence of resistant strain has aggravated the tuberculosis situation in the world, running out of control and hard to fight. We evaluate forty new quinoline analogues against sensitive and resistant Mycobacterium tuberculosis (Mtb).
Methods: The compounds were obtained via synthesis and evaluated against sensitive strain ATCC 27294.
Purpose: Due to serious problems with the treatment of leishmaniasis all around the world, here is an urgent need in the search for new drugs that are more effective and safer for the treatment of the various forms of leishmaniasis. Actual therapy is limited and lacks sufficient efficacy due to incomplete elimination of the parasites form of patients. In this sense, we decided to evaluate, by first-time, a series of seventeen camphor hydrazone derivatives (2a-2p) against Leishmania amazonensis.
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