A Novel Podophage Encodes a Unique Lysin with Unusual Modular Design.

Drug-resistant staphylococci, particularly and , are leading causes of hospital-acquired infections. Bacteriophages and their peptidoglycan hydrolytic enzymes (lysins) are currently being explored as alternatives to conventional antibiotics; however, only a limited diversity of staphylococcal phages and their lysins has yet been characterized. Here, we describe a novel staphylococcal phage and its lysins.