Publications by authors named "Gabriel C Riedemann"
Background: Cardiac hypertrophy compensates for increased biomechanical stress of the heart induced by prevalent cardiovascular pathologies but can result in heart failure if left untreated. Here, we hypothesized that the membrane fusion and repair protein dysferlin is critical for the integrity of the transverse-axial tubule (TAT) network inside cardiomyocytes and contributes to the proliferation of TAT endomembranes during pressure overload-induced cardiac hypertrophy.
Methods: Stimulated emission depletion and electron microscopy were used to localize dysferlin in mouse and human cardiomyocytes.
Article Synopsis
- S100A1 is a small protein that helps control calcium levels in muscles, which is important for how they work.
- Researchers studied how S100A1 attaches to a big calcium channel in muscle cells called the ryanodine receptor (RyR).
- When calcium is present, S100A1 changes shape and sticks to RyR even more tightly, which could help scientists create new treatments for muscle diseases.