Publications by authors named "Gabriel C Gauthier"
Dual-Peak Lorentzian CEST MRI for antiretroviral drug brain distribution.
NeuroImmune Pharm Ther
March 2023
Article Synopsis
- Researchers developed a new algorithm to improve the accuracy of CEST MRI methods for tracking antiretroviral drugs (ARVs) in tissues, which previously faced limitations due to interference from biomolecules.
- The algorithm was specifically tested on lamivudine (3TC), a common ARV, and successfully fitted its proton peaks, providing a more precise measurement of 3TC's presence in the brains of treated mice.
- The results showed that this dual-peak fitting method correlated better with actual drug levels compared to traditional methods, indicating a significant advancement for the mapping of various ARVs using CEST MRI.