Investigating the significance of the transgenerational impact of high and repeated doses of ivermectin: Effects on paternal testis histopathology, pups' development, and sexual behavior.

Paternal exposure to environmental challenges is critical for the offspring's future health, and the transmission of acquired traits through generations increases the risk of offspring developing diseases. Ivermectin (IVM) is widely used in veterinary and human medicine to treat parasitosis. Our previous studies showed that IVM acute administration induced disorganization of the germinal epithelium and could cause damage to sperm production.