Efficacy and Safety of Andexanet Alfa Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta-Analysis.

Factor Xa inhibitors (FXaI) are increasingly used for anticoagulation therapy, yet their association with intracranial hemorrhage poses a significant challenge. Although andexanet alfa (AA) and four-factor prothrombin complex concentrate (4F-PCC) have shown promise in reversing FXaI effects, their comparative efficacy and safety remain uncertain. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a literature search on electronic databases to obtain the relevant studies until May 16, 2024.

Profiling of two species using LC-ESI/MS with evidence of their hepatoprotective activity.

and are only reported to have significant cytotoxic activity against certain cancer cell lines with phytochemical investigation of their petroleum ether and the ethyl acetate extracts. Further investigation was suggested concerning their hepatoprotective activity and relating it to the metabolic profile of their defatted methanol extracts using LC-ESI/MS analysis. Hepatoprotective activity was evaluated through assessment of three liver parameters as well as liver histopathological examination in thioacetamide-induced hepatotoxicity model.

Structural characterization of three cytotoxic steroidal saponins from the leaves of Agave desmetiana hort.

Three steroidal saponins detected by LC-MS were isolated from the leaves of Agave desmetiana hort. The three saponins were characterized as; Tigogenin 3 - [{O - β - D - xylopyranosyl (1 → 2) - α - L-rhamnopyranosyl (1 → 3)}-β-D- glucopyranoside), Tigogenin- 3 - ([O- α -L-rhamnopyranosyl (1 → 3) - β - D - glalactopyranosyl (1 → 2)] - β - D - glucopyranoside) and Tigogenin- 3 - ([{O - α - L - rhamnopyranosyl (1 → 4)} - β - D - galactopyranosyl (1 → 3) - β - D - xylopyranosyl (1 → 2)] - β - D - glucopyranoside). Identification and structure elucidation of the isolates were done via 1D and 2D NMR techniques, and chemical methods.

Phytochemical investigation of and family Aizoaceae and evaluation of their cytotoxic activity.

This study aims to shed light on the phytochemical composition and the biological effect of two members of family and Gas chromatography coupled to mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) was used to investigate the lipoidal matter and the phenolic content, respectively. The MTT assay was used to evaluate the cytotoxic activity against MCF-7 (breast cancer), HepG2 (liver cancer) and HCT-116 (colorectal cancer) cell lines. The total phenolic acids and the total flavonoid content of were found to be higher than that of Phytol, hexadecanoic acid, -coumaric, ferulic and - hydroxybenzoic acids were the major detected compounds.

Production of Terretonin N and Butyrolactone I by Thermophilic TM8 Promoted Apoptosis and Cell Death in Human Prostate and Ovarian Cancer Cells.

The anticancer activity of terretonin N () and butyrolactone I (), obtained from the thermophilic fungus TM8, was intensively studied against prostate adenocarcinoma (PC-3) and ovary adenocarcinoma (SKOV3) human cell lines. According to this study, both compounds showed potent cytotoxicity towards ovarian adenocarcinoma cells (SKOV3) with IC 1.2 and 0.

Isolation and Identification of Pathogenic Acanthamoeba Species from Air Conditioning Systems, Egypt.

Acanthamoeba are free-living amoebae that cause granulomatous amoebic encephalitis and keratitis. In this study, we aimed to isolate and identify Acanthamoeba from air conditioning systems using in vitro cell culture and polymerase chain reaction assays. We also estimated the pathogenicity of the isolates by measuring their thermotolerance and studying mice models inoculated with these isolates.

The anti-inflammatory, anti-ulcer activities and phytochemical investigation of L. cv. Ismailawi fruits.

This study aims to evaluate the anti-inflammatory and anti-ulcer activities of L. cv. Ismailawi fruits, as well as the investigation of the phenolic content and lipoidal matter composition via high performance liquid chromatography and gas chromatography coupled to mass spectrometry respectively.

Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts.

The green synthesis of silver nanoparticles (SNPs) using plant extracts is an eco-friendly method. It is a single step and offers several advantages such as time reducing, cost-effective and environmental non-toxic. Silver nanoparticles are a type of Noble metal nanoparticles and it has tremendous applications in the field of diagnostics, therapeutics, antimicrobial activity, anticancer and neurodegenerative diseases.

Antiviral potential of green synthesized silver nanoparticles of and .

Background: Viral and microbial infections constitute one of the most important life-threatening problems. The emergence of new viral and bacterial infectious diseases increases the demand for new therapeutic drugs.

Purpose: The objective of this study was to use the aqueous and hexane extracts of and F.

Molecular characterization of Cryptosporidium isolates from humans by nested polymerase chain reaction - restriction fragment length polymorphism (nPCR-RFLP) analysis in Egypt.

ryptosporidium species is a group of protozoan parasites recognized as a cause of diarrhea with significant morbidity and mortality in industrialized and developing countries. Cryptosporidium hominis and Cryptosporidium parvum seem to be the most common causes of human cryptosporiodosis, however, other species are also found. Hence, the present study aimed to determine Cryptosporidium spp.

Comparison between ELISA and various stains techniques in laboratory diagnosis of cryptosporidiosis.

Cryptosporidium spp. is an important parasitic protozoa causing diarrhea which is a severe life-threatening diarrhea especially in immunocompromised hosts. We aimed to evaluate the usefulness of detection of Cryptosporidium spp.

The epidemiology of schistosomiasis in Egypt: summary findings in nine governorates.

Health questionnaires and parasitologic examinations of urine and stool were evaluated from a stratified random sample of 89,180 individuals from 17,172 households in 251 rural communities in 9 governorates of Egypt to investigate the prevalence of, risk factors for, and changing pattern of infection with Schistosoma sp. in Egypt. A subset, every fifth household, or 18,600 subjects, had physical and ultrasound examinations to investigate the prevalence of and risk factors for morbidity.

The epidemiology of schistosomiasis in Egypt: Minya Governorate.

Risk factors, prevalence, and intensity of infection with Schistosoma sp. and prevalence and magnitude of morbidity caused by schistosomiasis was assessed in a stratified random sample of 16,433 subjects from 2,409 households in 33 rural communities in Minya Governorate, Egypt. The prevalence of S.

Determinants of infection with schistosomiasis haematobia using logistic regression.

A population-based stratified random sample of 10,039 inhabitants of rural communities in Minya Governorate, Egypt, were evaluated for risk factors for Schistosoma haematobium infection using multivariate analysis. Data were obtained by personal interview recording demographics, information on exposure to canal water, history of infection, and other risk factors for infection and examining urine samples for S. haematobium ova.

Hematuria and proteinuria as predictors of Schistosoma haematobium infection.

An investigation of a population-based stratified random sample of 11,970 inhabitants of Minya Governorate in Egypt included examining urine specimens for Schistosoma haematobium ova using the filtration technique and for hematuria and proteinuria using reagent strips. Age- and gender-specific sensitivity, specificity, predictive values, and likelihood ratios of reagent strip-detected hematuria and proteinuria as indicators of S. haematobium infection were assessed.

Evaluating the detection of circulating filarial antigen in diagnosis of bancroftian filariasis and filarial hydrocele.

Four groups of patients were selected: 16 patients with clinical evidence of obstructive filarial lymphangiopathy without microfilaraemia; 12 patients with clinical evidence of obstructive filarial lymphangiopathy with microfilaraemia and 9 patients with microfilaraemia. Two control groups were also included. Blood films, sera and hydrocele fluid samples were collected from all subjects.

Application of neural networks to the real-time diagnosis of acute toxoplasmic infection in immunocompetent patients.

Neural networks constitute a relatively new, radically different approach to the interpretation and recognition of subtle diagnostic patterns in multivariate data. In this study the use of neural networks with a single serum sample for rapid real-time recognition of recent toxoplasmic infection was investigated. A neural-network model was implemented on the basis of data obtained by four serological methods--dye test, indirect fluorescence assay, indirect hemagglutination assay, and IgM immunosorbent agglutination assay--and was "trained" to extract features of acute infection by application to an analysis of 65 immunocompetent patients, 10 of whom were in fact acutely infected.

Suppression of immunopathology in schistosomiasis by interleukin-2-targeted fusion toxin, DAB389IL-2. I. Studies of in vitro and in vivo efficacy.

Schistosomiasis causes pathology in an estimated 200 million individuals. Clinical disease is caused by a complex immunopathologic response to the parasite ova, which are deposited in the host tissues. This immunopathologic response is caused by T lymphocytes which express the high-affinity IL-2 receptor (IL-2R).

Seasonal variation of sandflies in Beni-Suef, Egypt.

The sandflies were collected from Beni-Suef district over one year, and identified as P. papatasii, P. sergenti and Sergentomia m.

Relation of parasitic infection to blood group in El Minia Governorate, Egypt.

148 patients attending the outpatient Tropical Medicine clinic, El Minia University Hospital were studied for parasitic infections in relation to ABO blood groups. There was a statistically significant relationship between G. lamblia infection (69.

Studies on the enteric helminths infecting Clarias lazera in El-Minia Governorate, Egypt.

Clarias lazera fishes have been examined for helminth parasites. The following parasites were identified Orientocreadium batrachoides (Tunbangui, 1931), Glossidium pedatum (Looss, 1899), Polyonchoborthrium clarias (Woodland, 1925), Procmaollanus leveiconchus (Railliet and Henery, 1915) and Paracamallans cyathopharynx (Baylis, 1932).