Publications by authors named "Gabor Janos Szebeni"
Article Synopsis
- Germline pathogenic variants in certain genes indicate genetic susceptibility to hereditary breast and ovarian cancer syndrome, highlighting the role of tumor-immune interactions in breast cancer development.
- A study of 66 women revealed alterations in four immune cell subpopulations between healthy controls and those with a genetic predisposition; however, no significant differences were found between healthy carriers and controls.
- Three of these immune subpopulations were also found to be elevated in triple-negative breast cancer patients, suggesting an activated immune response in healthy gpath() carriers that could inform future risk-reducing strategies.
Bone marrow derived mesenchymal stromal cells (MSCs) have recently been implicated as one source of the tumor-associated stroma, which plays essential role in regulating tumor progression. In spite of the intensive research, the individual factors in MSCs controlling tumor progression have not been adequately defined. In the present study we have examined the role of galectin-1 (Gal-1), a protein highly expressed in tumors with poor prognosis, in MSCs in the course of tumor development.
View Article and Find Full Text PDFGalectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence tumor cell-induced T-cell death, we applied co-cultures of tumor cells and T-cells thus avoiding artificial circumstances generated using recombinant protein.
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