Polyoxygenated Stigmastane-Type Steroids from Sch. Bip. ex Walp. and Their Chemophenetic Significance.

Four polyoxygenated stigmastanes (-) alongside known analogues (-) and flavonoids (-) were isolated from a dichloromethane/methanol (1:1, /) extract of the whole plant of Sch. Bip. ex Walp.

Demystifying racemic natural products in the homochiral world.

Natural products possess structural complexity, diversity and chirality with attractive functions and biological activities that have significantly impacted drug discovery initiatives. Chiral natural products are abundant in nature but rarely occur as racemates. The occurrence of natural products as racemates is very intriguing from a biosynthetic point of view; as enzymes are chiral molecules, enzymatic reactions generating natural products should be stereospecific and lead to single-enantiomer products.

Insecticidal Activities of L., Spenn. and L. against (Cockerell) under Laboratory and Greenhouse Conditions.

The wild cochineal (Hemiptera: Dactylopiidae) is one of the major insect pests of the prickly pear (L.) in Morocco, a well-known fruit and vegetable crop of arid and semi-arid regions around the world. The present study investigated the insecticidal potential of six extracts (three aqueous and three hydroalcoholic (MeOH/HO, 20/80 (/)) from (leaves), (leaves) and (seeds) to control nymphs and adult females of under laboratory and greenhouse conditions.

Demystifying racemic natural products in the homochiral world.

Natural products possess structural complexity, diversity and chirality with attractive functions and biological activities that have significantly impacted drug discovery initiatives. Chiral natural products are abundant in nature but rarely occur as racemates. The occurrence of natural products as racemates is very intriguing from a biosynthetic point of view; as enzymes are chiral molecules, enzymatic reactions generating natural products should be stereospecific and lead to single-enantiomer products.

Two new flavone glycosides from the leaves of Oliv. (Ochnaceae).

Two new glycosylflavones, 6''--acetyl-8----galactopyranosylchrysoeriol () and 8----galactopyranosylchrysoeriol () were isolated from the methanol extract of the leaves of Oliv., along with four known compounds namely 8----galactopyranosylapigenin (), ochnaflavone (), sitosterol-3--glucopyranoside () and -mannitol (). Isolation was performed chromatographically and the structures of the purified compounds were elucidated by analyzing their spectroscopic and mass spectrometric data.

Caper ( L.): An Updated Review on Its Phytochemistry, Nutritional Value, Traditional Uses, and Therapeutic Potential.

Caper ( L.) is a perennial shrub of the family Capparaceae, endemic to circum-Mediterranean countries. Caper carries a renowned nutritional value, especially in terms of vitamins and antioxidants related to the occurrence of flavonoids, alkaloids, and glucosinolates as main secondary metabolites.

Sesquiterpene Lactones from : Structural Characterization and Biological Evaluation.

The genus is an extremely rich source of biologically active sesquiterpene lactones. The present report describes the spectroscopic structure elucidation and the cytotoxic and antimicrobial properties of five hitherto unknown germacranolide-like sesquiterpenoids and several known compounds. These new derivatives include a compound () with an unprecedented 10/5/5/6 tetracyclic framework featuring a hexahydro-1,3,7-furo[3',4':3,4]furo[3,2-]pyridin-1-one core resulting from an intramolecular cyclization cascade involving a methacrylate substituent and a low molecular weight amine.

L. Alston: An Insight Into its Phytochemistry, Traditional Uses, and Pharmacological Properties.

Medicinal plants have been used since ancient times for human healthcare as drugs, spices, and food additives. The progress in technology and medicine observed, the last decades, has improved the quality of life and healthcare but with worrisome drawbacks. Side effects caused by synthetic drugs for instance originate sometimes irreversible health disorders.

Toward the Allelopathy of sp. and Related Chemical Constituents in Agriculture.

The genus constitutes one of the perennial groups of plants of semi-arid regions across the world. It produces diverse classes of metabolites with claimed valuable pharmacological applications. Despite the key chemical and biological properties of the genus, its allelopathy or that of one of its species has not been reviewed yet.

Alkenylbenzoquinones and other compounds from the fruit of exhibited potent cytotoxic, antibacterial, and antiradical scavenging activities.

A phytochemical study of the methanol extract of the fruit of resulted in the isolation of a new alkenylbenzoquinone (), alongside the known compounds ()-2,5-dihydroxy-6-methyl-3-(pentadec-10'-enyl)-1,4-benzoquinone (), 2,5-dihydroxy-6-methyl-3-(nonadec-14'-enyl)-1,4-benzoquinone (), 2,5-dihydroxy-6-methyl-3-(tridecyl)-1,4-benzoquinone (), (2,3,4,2',9E)-[2'-hydroxytetraeicosanoyl]-2-aminooctadec-9-ene-1,3,4-triol (), monopalmitin (glyceryl palmitate) (), lupeol (), and 3--(-D-glucopyranoside)--sitosterol (). The structures of the compounds were established by the means of spectroscopic (1 D- and 2 D-NMR) and spectrometric techniques (MS). The isolated compounds were assessed for their antibacterial, cytotoxic, and antiradical activities.

LC-ToF-ESI-MS Patterns of Hirsutinolide-like Sesquiterpenoids Present in the Kunth Extract and Chemophenetic Significance of Its Chemical Constituents.

A total of nine sesquiterpenoid lactones together with phenolic compounds and other terpenes were identified from the crude methanol extract of Kunth. Compounds were isolated using different chromatographic techniques and their structures were determined by NMR and IR spectroscopy as well as mass spectrometry. The structures of some detected compounds were assigned based on LC-ToF-ESI-MS screening of main fractions/subfractions from flash chromatography and comparison with isolated analogues as standards.

Two new triterpenoid fatty acid esters from Harms (Araliaceae).

Two new fatty acid esters of triterpenoids (-) together with eleven known compounds (-) were obtained after investigation of the CHCl-MeOH (1:1) crude extract from the leaves of Harms. All these compounds (-) were isolated for the first time from this plant among which compounds , , and - were also isolated from the genus for the first time. The structures of the isolated compounds were elucidated by analyses of their spectroscopic data (1D and 2D NMR, and MS).

New Alkenylresorcinols with Cytotoxic and Antimicrobial Activities from the Leaves of Embelia schimperi.

A phytochemical study of the methanol extract of the leaves of resulted in the isolation of three new alkenylresorcinols, 1:  - 3: , together with the known analogs 4:  - 7: . Their structures were established by a combination of spectroscopic techniques. Compounds 1:  - 7: exhibited moderate cytotoxic activity against human cervical cancer cells HeLa-S3 and more pronounced antimicrobial properties towards bacteria and filamentous fungi.

Anti-inflammatory norhopanes from the root bark of Fagaropsis angolensis (Engl.) H.M.Gardner.

Two new norhopane derivatives namely 3β,6β,22-trihydroxy-7β,11α-di[(4-hydroxybenzoyl)oxy]-21αH-24-norhopa-4(23)-ene (1) and 3β,6β,22-trihydroxy-7β-[(4-hydroxybenzoyl)oxy]-21αH-24-norhopa-4(23)-ene (2) together with two previously reported compounds, including a norhopane, 3β,6β,11α-trihydroxy-7β-[(4-hydroxybenzoyl)oxy]-24-norhopa-4(23),17(21)-diene (3) and a norneohopane, (21αH)-24-norneohopa-4(23), 22(29)-diene-3β,6β,7β-triol 7-caffeate (4) were isolated from the root bark of Fagaropsis angolensis. Elucidation of their structures was achieved by spectroscopic (NMR, IR and UV) and spectrometric (HRESIMS) data and by comparison of these data with those of related compounds in the literature. Compounds 1-4 were evaluated for their anti-inflammatory activity by measuring the levels of cytokines, IL-1β, IL-2, GM-CSF and TNF-α in lipopolysaccharide (LPS) stimulated peripheral blood mononuclear cells (PBMC).

A new ceramide from the leaves of (Hochst. ex A.Rich.) Engl.

A new ceramide is being reported herein together with six known compounds from the methanol extract of the leaves of (Hochst. ex A.Rich.

Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae).

Background: The proliferation and resistance of microorganisms area serious threat against humankind and the search for new therapeutics is needed. The present report describes the antiplasmodial and anticancer activities of samples isolated from the methanol extract of Albizia zygia (Mimosaseae).

Material: The plant extract was prepared by maceration in methanol.

-clerodane diterpenoids from Sch.Bip. ex A.Rich.

Two hitherto unknown -clerodane-type diterpenoids along with twelve known compounds have been isolated from Sch.Bip. ex A.

Caffeate and piperidine-3-ol derivatives from the stem bark of .

A new caffeate derivative from the ethanol extract of the stem bark of DC. is described herein along with the known secondary metabolites spectaline (), -6-cassine (), 3--methyl--inositol (), monobehenin (), octyl nonadecyloate (), -sitosterol (), stigmasterol () and sitosterol 3---D-glucopyranoside (). The chemical structures were elucidated by means of various spectroscopic and spectrometric techniques.

A new polyketide from the bark of Schimp. (Hypericaceae).

The isolation and spectroscopic data of a hitherto undescribed polyketide () from Schimp. (Hypericaceae) together with six known compounds (-) is herein reported. The structure elucidation is based on extensive 1D- and 2D-NMR, infrared, UV and MS experiments.

Saponin with antibacterial activity from the roots of .

An unprecedented saponin is being reported herein together with five known compounds from the methanol extract of the roots of . The metabolites were obtained over repeated open column chromatography methods and spectroscopic followed by spectrometric techniques. The isolated compounds were tested against eleven Gram-negative bacteria including multidrug resistant strains.

Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.

Two new furoquinoline alkaloids, maculine B (1) and kokusaginine B (2) and one new dihydrooxazole alkaloid, veprisazole (3), along with four known compounds namely, N-methyl-3-methoxyrutaecarpine (4), flindersiamine (5), skimmianine (6) and tilianin (7) were isolated from the methanol extract of the stem bark of Araliopsis soyauxii Engl. by various chromatographic methods. Their structures were determined using spectrometry and spectroscopic techniques including NMR and MS.

Guttiferone BL with antibacterial activity from the fruits of .

genus, an endless source of bioactive compounds, was investigated for its antibacterial properties. The chemical study of the methanol extract from the fruits of resulted in the isolation of the undescribed guttiferone BL () along with the known kaempferol (), morelloflavone (), morelloflavone 7″---D-glucopyranoside (), -sitosterol 3---D-glucopyranoside and -sitosterol. Their structures were determined using spectrometry and spectroscopic techniques.

Ericoside, a new antibacterial biflavonoid from Erica mannii (Ericaceae).

A new dihydroflavonol-flavonol biflavonoid derivative, named ericoside was isolated from the ethanol extract of the whole plant of Erica mannii along with the known flavonoid, taxifolin 3-O-α-L-rhamnopyranoside; and two readily available sterols (sitosterol, sitosterol 3-O-β-D-glucopyranoside). The isolation was performed using chromatographic methods and the structure of purified molecules were elucidated using spectroscopic techniques (e.g.

Antibacterial activity of ethanolic extract and compounds from fruits of Tectona grandis (Verbenaceae).

Background: Well known as teak, Tectona grandis is widely used in African folk medicine for its pharmacological relevance. In Cameroon, this species is a reputed laxative in the Northern Region while in the Western Region, it is used in the treatment of skin diseases and diarrhoea.

Materials And Methods: Separation and isolation of compounds were performed using different chromatographic methods while their structures were elucidated by spectroscopic techniques including MS and NMR, and by comparison of data with those reported in the literature.