Publications by authors named "Gabet A"
Epidemiology of cardiovascular risk factors: Behavioural risk factors.
Arch Cardiovasc Dis
December 2024
Article Synopsis
- * A significant portion of the French population engages in unhealthy behaviors: one-third smoke, 71.7% don’t consume enough fruits and vegetables, and many fail to meet physical activity guidelines.
- * Although there are some improvements, like increased physical activity in men and reduced smoking rates, serious concerns remain, especially as women's health behaviors begin to mirror those of men, highlighting the need for enhanced prevention efforts.
Background: Hypertension is the most common chronic disease and a major modifiable risk factor for cardio-cerebrovascular and renal diseases. This study estimated the national burden of hypertension, defined as systolic blood pressure ≥140 mm Hg, on morbidity and mortality in 2021 in France.
Methods: For all diseases causally associated with hypertension (cardiovascular diseases, chronic kidney diseases, and dementia), the number and proportion of cases attributable to hypertension in adults aged ≥35 years were estimated using population attributable fractions.
Article Synopsis
- The study reviews the management and outcomes of stroke cases in France, revealing significant data from the year 2022 after nearly a decade of a national stroke plan.
- In total, 122,422 adults were hospitalized for stroke, with stark variations in care based on geographic and socioeconomic factors, and low rates of advanced treatments like mechanical thrombectomy.
- The findings indicate high mortality rates within a year post-stroke and call for improved prevention strategies, better public awareness of stroke symptoms, and enhanced accessibility to stroke care services.
Epidemiology of aortic and peripheral arterial diseases in France.
Arch Cardiovasc Dis
December 2024
Background: Peripheral arterial diseases (PADs) account for much of the morbidity and hospitalizations experienced by patients with cardiovascular disease. Epidemiological data on these diseases are lacking in France.
Aims: To describe the epidemiology of aortic diseases (aneurysm and dissection) and PADs in France in 2022.
Background: Demographic changes and improvements in the diagnosis and treatment of valvular heart diseases (VHDs) have led to changes in its epidemiological profile.
Aims: To describe the epidemiology of VHD in France in 2022.
Methods: Adults hospitalized due to VHD in 2022 were identified from the French National Health Data System and categorized by type of VHD on the basis of hospital diagnoses and interventions.
Background: Few epidemiological data are available for venous thromboembolism (VTE) at French national and subnational levels.
Aims: To quantify VTE events in France in 2022 and describe the features of hospital management and outcomes.
Methods: Adults hospitalized for a VTE as the primary reason for hospitalization or treatment in a medical unit in 2022 were identified from medical administrative data.
Background: Elevated concentrations of low-density lipoprotein cholesterol (LDL-C) are highly prevalent and are associated with the development of cardiovascular diseases.
Aim: To estimate the proportion of cardiovascular disease cases attributable to high concentrations of LDL-C (population attributable fraction [PAF]) in France in 2017, based on the most recent individual data on LDL-C, and the attributable burden on hospitalizations and death.
Methods: We estimated the PAF of high LDL-C concentrations for ischaemic heart disease (IHD), ischaemic stroke and aortic valve stenosis (AVS).
Article Synopsis
- The study investigates heart failure (HF) hospitalization in France post-pandemic, focusing on incidence, prevalence, patient characteristics, management, and outcomes based on sex, age, and socio-economic status.
- Utilizing a comprehensive health care database, findings reveal a prevalence rate of 1.7% in France, with an overall decrease in acute HF decompensation incidence since 2012, particularly among men under 45.
- Despite improvements in management and a decline in one-year rehospitalization rates, one-year mortality rates remain high, especially among younger women and the most deprived areas.
Article Synopsis
- - In 2022, France recorded 242,227 hospitalizations due to ischaemic heart disease (IHD), affecting 5.6% of the adult population, with a significant mortality rate of 4.8% of all deaths being IHD-related.
- - Patients hospitalized for IHD had an average age of 69.3 years, with 29% being women; there was a high prevalence of cardiovascular risk factors, and many underwent interventions like percutaneous coronary interventions.
- - One year post-hospitalization, 29.9% of patients were rehospitalized for IHD, and 9.3% died from all causes, highlighting the need for improved prevention strategies for IHD in France.*
Article Synopsis
- - In 2022, France recorded 181,178 hospitalizations for heart failure (HF), yielding a prevalence rate of 2.6% among adults, while hospitalization rates were notably higher in socioeconomically deprived areas.
- - The overall hospital fatality rate for HF was 10.2%, with a significant increase to 34.0% within a year; however, only 20.1% of patients were admitted to rehabilitation within six months.
- - The findings highlight the need for improved cardiovascular prevention strategies and adaptations in healthcare services across different regions in France, emphasizing the importance of better adherence to treatment guidelines.
Article Synopsis
- Heart rhythm and conduction disorders vary in severity and can be benign or life-threatening, with a focus on their epidemiology in France.
- A study analyzed hospitalization data from 2022 and mortality from 2021 to assess the prevalence of three main conditions: atrial fibrillation/flutter, conduction disorders, and ventricular tachycardia/cardiac arrest.
- Findings revealed over 2.7 million individuals impacted by these disorders as of January 2023, with significant hospitalization rates and a concerning 44% mortality rate for those hospitalized due to ventricular tachycardia/cardiac arrest.
Epidemiology of cardiovascular risk factors: Non-behavioural risk factors.
Arch Cardiovasc Dis
December 2024
Article Synopsis
- Cardiovascular disease is the leading cause of death globally and a major concern in France, heavily influenced by modifiable risk factors like obesity, diabetes, hypertension, and high cholesterol levels.
- In 2015, significant prevalence rates for these conditions were reported among adults aged 18-74, with obesity at 17.2% and diabetes at 7.4%, yet awareness of these conditions was low among those affected.
- A push for better prevention methods, especially through nutrition and education, is essential to tackle these cardiovascular risk factors, with a noted importance on also addressing women's specific health issues that impact cardiovascular risk.
Article Synopsis
- Cardiovascular diseases (CVDs) and strokes are the top causes of death globally, motivating a comprehensive study on their incidence and hospitalizations in France for adults and pregnant women.
- In 2022, over 1.2 million adults were hospitalized for CVD, with a higher rate in men and those of lower socioeconomic status, while CVD caused approximately 138,137 adult deaths in 2021.
- Among children, congenital heart defects affected 3,876 infants in early 2022, and for pregnant women between 2010-2018, there were 1,261 strokes and 225 acute coronary syndromes, highlighting the urgent need for better prevention and management strategies for CVD.
Aims: To evaluate the impact of cardiac rehabilitation (CR) on optimization of secondary prevention treatments for acute coronary syndrome (ACS), medication persistence, medical follow-up, rehospitalization, and all-cause mortality.
Methods And Results: The National Health Insurance database was used to identify all patients hospitalized for ACS in France in 2019 and those among them who received CR. Patients' characteristics and outcomes were described and compared between CR and non-CR patients.
Background: Infection may trigger pediatric arterial ischemic stroke (PAIS), notably when related to focal cerebral arteriopathy. Community- and individual-level nonpharmaceutical interventions during the COVID-19 pandemic resulted in a major decrease in pediatric viral infections. We explored the consequences on the incidence of PAIS.
View Article and Find Full Text PDFBackground: We aimed to evaluate the impact of hypertensive disorders of pregnancy occurrence, recurrence, onset time, and severity on mortality and on a wide range of cardiovascular outcomes in France.
Methods And Results: CONCEPTION (Cohort of Cardiovascular Diseases in Pregnancy) is a French nationwide prospective cohort using data from the National Health Data System. We included all women in CONCEPTION with no history of a cardiovascular event who delivered in France for the first time between 2010 and 2018 (N=2 819 655).
Objectives: To estimate the number of cases and deaths related to hemorrhagic stroke (HS) attributable to a chronic alcohol consumption and to heavy episodic drinking (HED) in France.
Methods: A population-attributable fraction (PAF) estimation approach was used. Relative risks for HS with alcohol consumption were extracted from the INTERSTROKE study.
Background: Cardiac rehabilitation after an acute coronary syndrome is recommended to decrease patient morbidity and mortality and to improve quality of life.
Aims: To describe time trends in the rates of patients undergoing cardiac rehabilitation after an acute coronary syndrome in France from 2009 to 2021, and to identify possible disparities.
Methods: All patients hospitalized for acute coronary syndrome in France between January 2009 and June 2021 were identified from the national health insurance database.
Aims: To estimate the time trends in the annual incidence of patients hospitalized for acute coronary syndrome (ACS) in France from 2009 to 2021 and to analyse the current sex and social differences in ACS, management, and prognosis.
Methods And Results: All patients hospitalized for ACS in France were selected from the comprehensive National Health Insurance database. Age-standardized rates were computed overall and according to age group (over or under 65 years), sex, proxy of socioeconomic status, and ACS subtype [ST-segment elevation (STSE) and non-ST-segment elevation].
The degradation of a mixture of ibuprofen, naproxen, and diclofenac in various effluents by UVC/HO or UVC/SO was studied to assess the impact of the matrix composition and of the oxidant precursor on process efficiency. Experiments were carried out in a 20-L laboratory pilot (a scaled-down version of a full-scale pilot). In effluents collected during dry weather, the rural constructed wetland effluent allowed faster degradation than the urban conventional WWTP effluent, regardless of the nature of the targets or of the oxidant precursor.
View Article and Find Full Text PDFImportance: Women with pregnancy-associated stroke might have different risks of stroke recurrence, including during subsequent pregnancies, and other cardiovascular events due to pregnancy-specific stroke risk factors, such as gestational hypertension, preeclampsia, or gestational diabetes.
Objective: To estimate the rate of stroke recurrence, cardiovascular hospitalization, and death in women with pregnancy-associated stroke compared with women with non-pregnancy-associated stroke.
Design, Setting, And Participants: This cohort study included all women aged 15 to 49 years in France who were affiliated with the general scheme of French health care insurance (94% of women) and had a first hospitalization for stroke between January 1, 2010, and December 31, 2018.
Article Synopsis
- In France, cardiovascular disease rates are rising, particularly among young people, highlighting the need for targeted health promotion strategies.
- A study analyzed data from 1673 individuals aged 18-74 to identify different cardiovascular health profiles based on key risk factors like diet, physical activity, and smoking.
- Five profiles emerged, revealing a significant prevalence of poor cardiovascular health among older men with low socioeconomic status and young women, which can inform future public health campaigns aimed at improving cardiovascular health in the population.
Introduction: Intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) in women with ischemic stroke (IS) during pregnancy/post-partum is challenging, and recent guidelines claimed for additional information to better argue its effectiveness and safety. This observational national study aimed to describe characteristics, rates and outcomes of pregnant/post-partum women receiving acute revascularization therapy for IS compared to their non-pregnant counterparts, and pregnant women with IS not receiving such therapy.
Patients And Methods: In this cross-sectional study, all women aged 15-49 years hospitalized in France for IS between 2012 and 2018 were retrieved from the French hospital discharge databases.
The emergence of SARS-CoV-2 variants calls for continuous monitoring of vaccine effectiveness (VE). We estimated the absolute effectiveness of complete 2-dose primary vaccination and booster vaccination with COVID-19 mRNA vaccines, and the duration of protection against Delta and Omicron BA.1 symptomatic infection and severe outcomes.
View Article and Find Full Text PDFBackground: Many clinical trials have reported that low-dose aspirin decreases the risk of pre-eclampsia in women with prior pre-eclampsia. However, its impact in a real-world population has not been fully assessed.
Objectives: To assess the rates of low-dose aspirin initiation during pregnancy in women with a history of pre-eclampsia, and to evaluate the impact of low-dose aspirin in prevention of pre-eclampsia recurrence in a real-world population.