Publications by authors named "Gabe Weininger"

Article Synopsis
  • Ascending thoracic aortic aneurysms are a major health risk, often leading to fatal outcomes like rupture or dissection, particularly in developed countries.
  • This review focuses on how understanding these aneurysms could reduce their associated health risks, especially their complex relationship with atherosclerosis.
  • The authors suggest various mechanisms, such as matrix metalloproteinases and transforming growth factor-β, that might explain the connection between aneurysms and lower rates of heart disease indicators like carotid thickness and LDL levels.
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Background: Median arcuate ligament syndrome (MALS) is a clinical syndrome caused by compression of the celiac artery by the median arcuate ligament that often manifests with nonspecific abdominal pain. Identification of this syndrome is often dependent on imaging of compression and upward bending of the celiac artery by lateral computed tomography angiography, the so-called "hook sign." The purpose of this study was to assess the relationship of radiologic characteristics of the celiac artery to clinically relevant MALS.

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In experienced hands, complex mitral valve repair can be safely and effectively performed in a totally endoscopic, robotic-assisted manner. We present a technically complex case of a 76-year-old man with severe, symptomatic mitral regurgitation due to Barlow's disease, moderate-to-severe tricuspid regurgitation, and atrial fibrillation.

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Background: Natural history of atrial and ventricular secondary mitral regurgitation (SMR) is poorly understood. We compared the impact of the degree of SMR on survival between atrial and ventricular dysfunction.

Methods: We conducted a retrospective cohort study of patients who underwent echocardiography in a healthcare network between 2013-2018.

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Background: Median arcuate ligament syndrome (MALS) is a frequent differential diagnosis in patients with postprandial abdominal symptoms, but diagnosis remains challenging. The aim of this study was to identify characteristics of patients who had MALS compared with non-MALS patients among a cohort of patients diagnosed with celiac artery compression (CAC).

Study Design: An IRB-approved retrospective chart review (2000 to 2021) of patients at our institution with a discharge diagnosis of CAC was performed.

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Purpose: Loeys-Dietz syndrome (LDS) is a rare connective tissue disorder. In LDS patients with normal arch morphology, whether the arch should be prophylactically replaced at the time of proximal aortic replacement remains unknown. We evaluated the risk of long-term arch complications in genetically confirmed LDS patients who underwent proximal ascending aortic replacement.

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Background: Mitral valve repair durability currently plays a key role in operative decision making and in defining optimal surgical practice. However, mitral valve durability outcomes measures are not captured by national registries and limited to centers that publish their outcomes. In this study, we aim to describe the scope of institutions represented by reports describing durability outcomes after mitral valve repair within the contemporary literature.

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Background: Prior studies on ascending thoracic aortic aneurysm (ATAA) growth rates have reported approximately 1 mm of growth per year but these studies are based on referral-based study populations which are biased towards the highest risk patients who may not represent the true natural history of aortic aneurysm disease. We aimed to characterize the growth rate of ATAAs in a non-referral-based population, using a large institutional database of computed tomography (CT) scans.

Methods: We queried the 21,325 CT scans performed at our institution between 2013 and 2016 on patients ages 50-85 years old for radiologic diagnosis of aortic aneurysm or dilatation.

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Background: Thoracic aortic aneurysm (TAA) is a significant risk factor for aortic dissection and rupture. Guidelines recommend referral of patients to a cardiovascular specialist for periodic surveillance imaging with surgical intervention determined primarily by aneurysm size. We investigated the association between socioeconomic status (SES) and surveillance practices in patients with ascending aortic aneurysms.

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Background Screening protocols do not exist for ascending thoracic aortic aneurysms (ATAAs). A risk prediction algorithm may aid targeted screening of patients with an undiagnosed ATAA to prevent aortic dissection. We aimed to develop and validate a risk model to identify those at increased risk of having an ATAA, based on readily available clinical information.

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Background And Aim: In 2011, the Accreditation Council for Graduate Medical Education (ACGME) restricted the first-year residents' duty-hour to less than 16-hour shifts, decreased the maximum shift duration for senior residents, and increased minimum time off after on-call duties. Whether these changes may have impacted the outcomes in cardiac surgery remains unclear.

Methods: We performed a difference-in-difference analysis of the New York State Cardiac Surgery Reporting System data in 2004-2006 (before the duty-hour policies change) and 2014-2016 (after the change).

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Papillary fibroelastoma is a rare, benign tumor that affects males more frequently  than females and that tends to be diagnosed during the fifth or sixth decade of life. It tends to arise on cardiac valves, with the aortic valve being the most frequent location followed by the mitral valve, the tricuspid valve, and the pulmonary valve. We present the case of a robotic-assisted, totally endoscopic excision of a mitral valve papillary fibroelastoma.

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Vascular disorders frequently have differing clinical presentations among women and men. Sex differences exist in vascular access for hemodialysis; women have reduced rates of arteriovenous fistula (AVF) maturation as well as fistula utilization compared with men. Inflammation is increasingly implicated in both clinical studies and animal models as a potent mechanism driving AVF maturation, especially in vessel dilation and wall thickening, that allows venous remodeling to the fistula environment to support hemodialysis.

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Article Synopsis
  • The study investigates the survival rates of patients with mild secondary mitral regurgitation (SMR) compared to those without valvular abnormalities.
  • It includes a retrospective analysis of over 16,000 patients and finds that those with mild SMR and mild tricuspid regurgitation (TR) have a significantly higher risk of death.
  • The results suggest that even in patients with preserved left-ventricular ejection fraction (LVEF), mild SMR should be closely monitored due to its impact on survival.
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Introduction: While size thresholds exist to determine when aortic aneurysms warrant surgical intervention, there is no consensus on how best to treat this disease before aneurysms reach the threshold for intervention. Since a landmark study in 1994 first suggested ß-blockers may be useful in preventing aortic aneurysm growth, there has been a surge in research investigating different pharmacologic therapies for aortic aneurysms - with very mixed results.

Areas Covered: We have reviewed the existing literature on medical therapies used for thoracic and abdominal aortic aneurysms in humans.

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Article Synopsis
  • Mitral valve surgery faces challenges in patients with mitral annular calcification, leading to higher risks and no standard treatment approach, sometimes making surgery impossible.
  • A case study highlights successful treatment of severe calcification using a cavitron ultrasonic surgical aspirator, demonstrating its effectiveness.
  • A video tutorial accompanies the case, illustrating patient details, imaging, and the surgical technique, showing how proper use of this tool can reduce complications in surgery.
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Background: Ascending aortic aneurysms (AsAA) remain a silent killer for which timely intervention and surveillance intervals are critical. Despite this, little is known about the follow-up care patients receive after incidental detection of an AsAA. We examined the pattern of surveillance and follow-up care for these high-risk patients.

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