Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice.

Inoculation of newborn mice with lymphocytic chloriomeningitis (LCM) virus resulted in decreased weight gain, liver cell necrosis, and death. Injection of potent sheep immunoglobulin against mouse interferon markedly inhibited these manifestations of LCM virus disease despite the fact that these treated mice had 100-fold more LCM virus in their serum. We conclude that interferon induced by LCM virus is responsible in large part for the syndrome of growth inhibition, liver cell necrosis, and death observed in LCM virus-infected suckling mice.

[Adrenal scintigraphy using 131 I-19-iodocholesterol. Value in the exploration of Cushing's syndrome].

On the basis of 7 cases representing the essential types of aetiology of Cushing's syndrome, it is possible to define the value, limitations and role of adrenal scintigraphy using 131I-19-iodocholesterol in the diagnostic investigation of hypercortisolism. The essential value of the investigation is morphological rather than functional drome. Thus adrenal scintigraphy has the same role in diagnostic investigation as various radiological procedures such as pneumoperitoneum and angiography.

[Virological control of laboratory mice].

Virological control of laboratory mice can be obtained by serology or virus isolation from the animals. Advantages and inconveniencies of these two techniques are discussed. Special techniques i.

[Diabetes mellitus secondary to liver diseases. A review (author's transl)].

Diabetes mellitus is more frequently found in pateints with hepatic cirrhosis (about 10%) than in subjects without liver disease. Cirrhosis has been the main subject of interest in this respect. Very few studies have been made in viral hepatitis or steatosis.