[Absorption and excretion of g-strophanthin after intravenous or sublingual administration (author's transl)].

Tritiated g-strophanthin was administered to six volunteer patients in a dose of 0.25 mg intravenously and 6.0 mg sublingually 1-3 weeks apart.

Effects of vasopressin and its deamino-D-arginine analogue on renin release in the isolated perfused rat kidney.

The direct action of arginine-vasopressin (AVP) and its deamino-D-arginine analogue (DDAVP) on renin release (RR) has been studied in isolated rat kidneys perfused with an electrolyte solution at constant pressure in a single-pass system. AVP and DDAVP infused at various concentrations (80 to 2100 pg/ml and 80 to 8700 pg/ml, respectively) reduced volume and increased osmolality of urine in a dose-dependent way. High doses of AVP reduced renal perfusate flow and glomerular filtration rate while DDAVP had no effect on renal haemodynamics.

Renal vasoconstriction in glycerol-induced acute renal failure. Studies in the isolated perfused rat kidney.

1. Acute renal failure was produced in rats by the intramuscular injection of glycerol (6.1 mol/l 10 ml/kg).

Effect of saralasin and serum in myohaemoglobinuric acute renal failure of rats.

1. In rats deprived of food and water for 24 h acute renal failure was produced by the intramuscular injection of glycerol. Eight hours later plasma urea concentration had increased threefold despite a small rise in urine volume.

[Histomechanical studies on test specimens from hyaline cartilage under compressive loading with regard to rheology (author's transl)].

Modified rheological methods from high polymer physics (biorheology, historheology) have been applied to the testing of hyaline cartilage histomechanics. The following histomechanical properties of cartilage are discussed: transient behaviour, the influence of the mechanical history on the subsequent force-deformation processes, viscoelastic equilibrium status (histomechanical steady state), and relaxation phenomena in the pressure and tension range under alternating pressure-tension loading. Pressure force-time input and output curves in a closed loop system and the amplitude-increasing phenomenon under uniform sinus deformations with increasing superimposed linear deformation input were also demonstrated.

What makes the renin-angiotensin system a pathogenic factor?

Three types of renal hypertension in the rat have been compared with respect to blood pressure increase, activity of the RAS, and secretion of aldosterone and corticosterone: type I - unilateral stenosis of the renal artery in the presence of an intact contralateral kidney; type II - unilateral stenosis of the renal artery after contralateral nephrectomy; type III - bilateral stenosis of the renal arteries. Blood pressure rose more rapidly and reached higher values in type II and type III hypertension than in type I hypertension. In the latter group, the activity of the RAS was more stimulated than in types II and III.

Irreversible shock in rats after injection of microspheres into the renal artery.

After injection of microspheres into both renal arteries of rats, an irreversible shock syndrome develops, resulting in death within 4-12 h. Ligation of both renal pedicles after injection of microspheres prevents the shock. It is presumed that kininogenases released from the kidneys participate in the pathogenesis of the shock syndrome.