Regulation by complementary idiotypes. Ig protects the clone producing it.

A/He mice actively producing complementary or anti-idiotypic antibody directed against a combining site structure for phosphorylcholine (PC) have profound and long-lasting suppression of their response to PC. B cells from unresponsive mice are unresponsive in vitro, and attempts to demonstrate suppressor cells in unresponsive mice were unsuccessful. Although the process ultimately responsible for suppression has not been defined, suppression can be initiated by anti-idiotypic antibody alone and prevented by complementary Ig; i.

Three dimensional view of sign iconicity.

The data suggest that learners' backgrounds are influential in determining which signs will be most easily perceived as iconic, which means that iconicity should not be determined solely on a linguistic basis.

Selective isolation of young erythrocytes for transfusion support of thalassemia major patients.

Transfusion-induced hemochromatosis remains a major therapeutic complication in the management of thalassemia major patients. Using available blood cell component separators, a system has been devised to selectively harvest young red cells from transfusion support of these subjects. Red cell units isolated by this method have an average estimated mean cell age of 30 days, compared to 60 days for unfractionated blood, and contain 80% of the hemoglobin content of standard red cell units.

Influence of iconicity and phonological similarity on sign learning by mentally retarded children.

The acquisition sign-word pairs by verbal moderately and severely retarded children as a function of the iconicity and cheremic (phonological) similarity of the signs and the vocabulary age of the subjects was studied using a recall format (alternate learning and test trials) paired-associates paradigm. Results of an analysis of variance revealed that iconicity enhanced learning, similarity interfered with acquisition, and there was no effect of vocabulary age within the range studied. There were not interaction among the above variables.

Educator perceptions of accreditation.

A 25-item survey was developed to collect data for a paper delineating educators' concerns for accreditation. Distributed randomly in the instrument were statements relating to the constructive aspects of accreditation, the constraints on the effectiveness of accreditation, and the logistical short-comings of the accreditation process. Responses were separated into four categories of institutions and were subjected to computer analysis.

Evaluation of cardiac function in patients with thalassemia major.

The application of noninvasive techniques to the evaluation of cardiac function in iron overload has identified a high incidence of abnormalities in asymptomatic patients prior to the onset of overt cardiac deterioration. Of the tests we have used, radionuclide cineangiography appears to be the most sensitive because it can be conveniently applied during the physiological stress of exercise. Other tests of cardiac function that include stress are also likely to be more sensitive than resting measurements of cardiac function.

Detection of early cardiac dysfunction in patients with severe beta-thalassemia and chronic iron overload.

To detect early left ventricular dysfunction, we used radionuclide cineangiography to determine left ventricular ejection fraction during exercise in 24 patients with transfusion-dependent, congenital anemias, 21 of whom had severe beta thalassemia. Ejection fraction at rest was normal in 21 patients (greater than 45 per cent) and in all patients was 53 +/- 2 per cent (mean +/- S.E.

Chromosome analysis on 930 consecutive newborn children using quinacrine fluorescent banding technique.

Chromosome analysing using quinacrine fluorescence was performed on 930 consecutive newborn infants. The total incidence of major chromosome aberrations including numerical changes of the sex chromosomes, and structural changes of autosomes, was 0.54%.