A Case of Extended Duration Triple Antithrombotic Therapy in a Patient With an Intracranial Stent and Atrial Fibrillation.

Our case report presents the clinical management of a 77-year-old female with recurrent acute ischemic stroke (AIS) due to severe intracranial large artery atherosclerosis (LAA), requiring intracranial stenting complicated by new-onset atrial fibrillation (AF). This clinical scenario necessitated the use of triple antithrombotic therapy (TAT) with aspirin, ticagrelor, and apixaban. While guidelines recommend minimizing the duration of TAT or favoring alternative regimens due to bleeding risks, this case highlights the safe application of an extended duration TAT course in a high-risk patient.

Talent identification of 12-year old male Australian rules footballers: Physical advantages and prognosis for junior and senior national-level selection.

Talent identification focuses on the ability to identify and select young athletes who show potential for future sporting success. The aim of this study was to compare the anthropometry and physical performance of male youth Australian Football players selected and not selected into a high performance sports academy program. Its secondary aim was to determine whether selection into a talent development environment at 12 years old affects the odds of selection into subsequent junior national level representative and senior professional Australian Football programs.

Developing a curriculum on antimicrobial stewardship for pediatric residents: a needs assessment.

Objective: Identify essential components of a curriculum on antimicrobial stewardship (AS) for pediatric residents.

Design: Survey.

Setting: Academic tertiary care children's hospital.

From evidence to advice in France, Germany, and the UK: transparency, accountability, and participation in pandemic science advice.

Politicians often claim to be "following science" but their claims are, reasonably, disputed. To claim to be following the science can mean that scientific evidence affects or legitimates decisions. The evidence that politicians are following science often comes from formal systems of advice that translate science into advice.

Genome sequence data for 61 isolates of Xanthomonas campestris pv. campestris from Brassica crops in Serbia.

This Technical Resource describes genome sequencing data for 61 isolates of the bacterial pathogen pv. collected from and crops between 2010 and 2021 in Serbia. We present the raw sequencing reads and annotated contig-level genome assemblies and determine the races of ten isolates.

The potential of bacteriocins and bacteriophages to control bacterial disease of crops with a focus on spp.

Crop production plays a crucial role in ensuring global food security and maintaining economic stability. The presence of bacterial phytopathogens, particularly species (a key focus of this review), poses significant threats to crops, leading to substantial economic losses. Current control strategies, such as the use of chemicals and antibiotics, face challenges such as environmental impact and the development of antimicrobial resistance.

Community and multisector partner engagement in US Vision Zero plan development.

Background: Vision Zero aims to eliminate serious and fatal road injuries using a Safe System approach. Safe System principles establish that safety is a shared responsibility; this involves both multisector partners and community engagement. This descriptive study explored multisector partners and community engagement in the development of municipal Vision Zero plans.

Construction of intermolecular σ-hole interactions in rare earth metallocene complexes using a 2,3,4,5-tetraiodopyrrolyl anion.

The generation of noncovalent intermolecular interactions represents a powerful method to control molecular vibrations and rotations. Combining these with the axial ligand field enforced by the metallocene ligand scaffold provides a dual-pronged approach in controlling the magnetic-relaxation pathways for dysprosium-based single-molecule magnets (SMMs). Here, we present the first implementation of 2,3,4,5-tetraiodopyrrole (TIPH) in its anionic form [TIP] as a ligand in three isostructural rare-earth metal complexes Cp*RE(TIP) (1-RE, RE = Y, Gd, and Dy; Cp* = pentamethylcylopentadienyl), where the TIP ligand binds through the nitrogen and one iodine atom κ(N,I) to the metal centre.

A Virtual Functional Medicine-Based Interdisciplinary and Integrative Intervention for Gulf War Illness.

Introduction: The War-Related Illness and Injury Study Center at the VA New Jersey Health Care System (WRIISC-VANJ) serves as one of the three tertiary referral centers for combat deployed Veterans of all eras with medically unexplained or difficult-to-diagnose conditions that may be related to deployment-related exposures. Many of the Veterans seen at the WRIISC experience chronic multisymptom illness (CMI), also known as Gulf War Illness (GWI). Given the complexity and interconnectedness of symptoms, Veterans with GWI are often unlikely to produce meaningful results when addressing single symptoms.

A Four-Coordinate Pr Imidophosphorane Complex.

The imidophosphorane ligand, [NPBu] (Bu=tert-butyl), enables isolation of a pseudo-tetrahedral, tetravalent praseodymium complex, [Pr(NPBu)] (1-Pr), which is characterized by a suite of physical characterization methods including single-crystal X-ray diffraction, electron paramagnetic resonance, and L-edge X-ray near-edge spectroscopies. Variable-temperature direct-current magnetic susceptibility data, supported by multiconfigurational quantum chemical calculations, demonstrate that the electronic structure diverges from the isoelectronic Ce analogue, driven by increased crystal field. The four-coordinate environment around Pr in 1-Pr, which is unparalleled in reported extended solid systems, provides a unique opportunity to study the interplay between crystal field splitting and spin-orbit coupling in a molecular tetravalent lanthanide within a pseudo-tetrahedral coordination geometry.

Extreme Ultraviolet Reflection Spectroscopy of Lanthanides and Actinides Using a High Harmonic Generation Light Source.

Absorption spectroscopy probing transitions from shallow-core d and f orbitals in lanthanides and actinides reveals information about bonding and the electronic structure in compounds containing these elements. However, spectroscopy in this photon energy range is challenging because of the limited availability of light sources and extremely short penetration depths. In this work, we address these challenges using a tabletop extreme ultraviolet (XUV), ultrafast, laser-driven, high harmonic generation light source, which generates femtosecond pulses in the 40-140 eV range.

Pivot: partisan policy responses to COVID-19 health disparities.

How did partisanship influence rhetoric about, public opinion of, and policies that prioritize racial and ethnic health disparities of COVID-19 during the first wave of the pandemic between March and July 2020? In this retrospective, mixed-methods analysis using national administrative and survey data, we found that the rhetoric and policy of shared sacrifice diminished and partisan differences in pandemic policy increased once it became clear to political elites that there were major racial disparities in COVID-19 cases and deaths. We trace how first disparities emerged in data and then were reported in elite, national media, discussed in Congress, and reflected in public opinion. Once racial disparities were apparent, partisan divides opened in media, public opinion, and legislative activity, with Democrats foregrounding inequality and Republicans increasingly downplaying the pandemic.

Superoxide Radicals in Uranyl Peroxide Solids: Lasting Signatures Identified by Electron Paramagnetic Resonance Spectroscopy.

U(VI) peroxide phases (studtite and meta-studtite) are found throughout the nuclear fuel cycle and exist as corrosion products in high radiation fields. Peroxides are part of a family of reactive oxygen species (ROS) that include hydroperoxyl and superoxide species and are produced during alpha radiolysis of water. While U(VI) peroxides have been thoroughly investigated, the incorporation and stability of ROS species within studtite have not been validated.

A review of sources of resistance to turnip yellows virus (TuYV) in species.

Turnip yellows virus (TuYV; previously known as beet western yellows virus) causes major diseases of species worldwide resulting in severe yield-losses in arable and vegetable crops. It has also been shown to reduce the quality of vegetables, particularly cabbage where it causes tip burn. Incidences of 100% have been recorded in commercial crops of winter oilseed rape () and vegetable crops (particularly ) in Europe.

Electronic Structure of Three-Coordinate Fe and Co β-Diketiminate Complexes.

The β-diketiminate supporting group, [ArNCRCHCRNAr], stabilizes low coordination number complexes. Four such complexes, where R = -butyl, Ar = 2,6-diisopropylphenyl, are studied: (nacnac)ML, where M = Fe, Co and L = Cl, CH. These are denoted , , , and and have been previously reported and structurally characterized.

Intervalence Charge Transfer in Nonbonding, Mixed-Valence, Homobimetallic Ytterbium Complexes.

There are several reports of compounds containing lanthanide ions in two different formal oxidation states; however, there are strikingly few examples of intervalence charge transfer (IVCT) transitions observed for these complexes, with those few occurrences limited to extended solids rather than molecular species. Herein, we report the synthesis, characterization, and computational analysis for a series of ytterbium complexes including a mixed-valence Yb complex featuring a remarkably short Yb···Yb distance of 2.9507(8) Å.

N-cadherin and β1 integrin coordinately regulate growth plate cartilage architecture.

Spatial and temporal regulation of chondrocyte maturation in the growth plate drives growth of many bones. One essential event to generate the ordered cell array characterizing growth plate cartilage is the formation of chondrocyte columns in the proliferative zone via 90-degree rotation of daughter cells to align with the long axis of the bone. Previous studies have suggested crucial roles for cadherins and integrin β1 in column formation.

Orbitrap Mass Spectrometry and High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Enable the in-Depth Analysis of Human Serum Proteoforms.

Blood serum and plasma are arguably the most commonly analyzed clinical samples, with dozens of proteins serving as validated biomarkers for various human diseases. Top-down proteomics may provide additional insights into disease etiopathogenesis since this approach focuses on protein forms, or proteoforms, originally circulating in blood, potentially providing access to information about relevant post-translational modifications, truncations, single amino acid substitutions, and many other sources of protein variation. However, the vast majority of proteomic studies on serum and plasma are carried out using peptide-centric, bottom-up approaches that cannot recapitulate the original proteoform content of samples.

The Iterative Mindset Method: a neuroscientific theoretical approach for sustainable behavior change and weight-loss in digital medicine.

With the growing prevalence of chronic conditions driving 85% of all healthcare costs, digital health offers a promising opportunity to reverse disease and improve health at-scale. The healthcare industry's predominant approach to behavior change is performance-based with a focus on goals and tracking. This has not reversed the epidemic of chronic diseases and also can harm chronically ill and vulnerable patients via perceived failure-induced loss of motivation.

Pan-conserved segment tags identify ultra-conserved sequences across assemblies in the human pangenome.

The human pangenome, a new reference sequence, addresses many limitations of the current GRCh38 reference. The first release is based on 94 high-quality haploid assemblies from individuals with diverse backgrounds. We employed a k-mer indexing strategy for comparative analysis across multiple assemblies, including the pangenome reference, GRCh38, and CHM13, a telomere-to-telomere reference assembly.

Draft genome sequences for ten strains of species that have phylogenomic importance.

Here we report draft-quality genome sequences for pathotype strains of eight plant-pathogenic bacterial pathovars: pv. , pv. , pv.

Exploring Differences in Lanthanide Excited State Reactivity Using a Simple Example: The Photophysics of La and Ce Thenoyltrifluoroacetone Complexes.

A series of four lanthanide thenoyltrifluoroacetone (TTA) complexes consisting of two f (La and Ce) and two f (Ce) complexes was examined using steady-state and time-resolved spectroscopic techniques. The wide range of spectroscopic techniques presented herein have enabled us to discern the nature of the excited states (charge transfer, CT vs ligand localized, LL) as well as construct a Jablonski diagram for detailing the excited state reactivity within the series of molecules. The wavelength and excitation power dependence for these series of complexes are the first direct verification for the presence of simultaneous competing, noninteracting CT and LL excited states.