miR-217-5p NanomiRs Inhibit Glioblastoma Growth and Enhance Effects of Ionizing Radiation via EZH2 Inhibition and Epigenetic Reprogramming.

: CSCs are critical drivers of the tumor and stem cell phenotypes of glioblastoma (GBM) cells. Chromatin modifications play a fundamental role in driving a GBM CSC phenotype. The goal of this study is to further our understanding of how stem cell-driving events control changes in chromatin architecture that contribute to the tumor-propagating phenotype of GBM.

LIFE: A metric for mapping the impact of land-cover change on global extinctions.

Human-driven habitat loss is recognized as the greatest cause of the biodiversity crisis, yet to date we lack robust, spatially explicit metrics quantifying the impacts of anthropogenic changes in habitat extent on species' extinctions. Existing metrics either fail to consider species identity or focus solely on recent habitat losses. The persistence score approach developed by Durán .

Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis.

Objective: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). S1P receptor expression on cardiac cells is involved in cardiac conduction. We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events in the etrasimod UC clinical programme.

A little more conversation, a little more action, please: the carbon footprint of travelling to conferences of the European Health Psychology Society.

Introduction: The environmental impact of on-site conferences, with air travel as the primary contributor to greenhouse gas emissions, has prompted a surge in research in recent years. The objective of this report is to raise awareness and stimulate transformation in the organisation of meetings of the European Health Psychology Society (EHPS).

Methods: We conducted estimations of travel-related COeq emissions of EHPS conferences in 2019, 2022, and 2023, and performed projections for 2024 and 2025.

AAV-based gene delivery of antimicrobial peptides to combat drug-resistant pathogens.

Antimicrobial peptides (AMPs) have emerged as potential alternatives to conventional antibiotics due to their novelty and multiple mechanisms of action. Because they are peptides, AMPs are amenable to bioengineering and suitable for cloning and expression at large production scales. However, the efficient delivery of AMPs is an unaddressed issue, particularly due to their large size, possible toxicities, and the development of adverse immune responses.

Evaluation of Bayesian Maximum Entropy Data Fusion Approaches to Estimate Styrene, Benzene, Toluene, Ethylbenzene, and Xylenes and to Inform Epidemiological Analyses in the US Gulf States.

The Gulf States are home to industries emitting styrene, benzene, toluene, ethylbenzene, and xylenes (SBTEX). Presently, adverse health effects of ambient SBTEX exposure in highly polluted regions, such as the Gulf States, must be evaluated. Epidemiologists, however, are limited by inadequate estimates of ambient SBTEX.

Exploring Australian knowledge and practice for maternal postnatal transition of care between hospital and primary care: A scoping review.

Problem: Despite the significance of the perinatal period, postnatal care remains insufficient for optimising long-term health.

Background: The perinatal period is a vulnerable time in a woman's life-course health trajectory. Supporting transitions from hospital to primary care is essential to promote health and guide evidence-based follow-up care.

A phase I, randomized, placebo-controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults.

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection (LRTI) in infants worldwide. Nirsevimab, an extended half-life monoclonal antibody against RSV, is approved in China for the prevention of RSV lower respiratory tract disease in infants; however, global nirsevimab trials did not enroll Chinese infants. To inform the investigation of nirsevimab for the prevention of RSV LRTI in Chinese infants, this Phase I, randomized, placebo-controlled trial evaluated the pharmacokinetics (PK) and safety of nirsevimab in healthy Chinese adults.

Competing mechanisms for the buckling of an epithelial monolayer identified using multicellular simulation.

A model using the rigid body multi-cellular framework (RBMCF) is implemented to investigate the mechanisms of buckling of an epithelial monolayer. Specifically, the deformation of a monolayer of epithelial cells which are attached to a basement membrane and the surrounding stromal tissue. The epithelial monolayer, supporting basement membrane and stromal tissue are modelled using two separate vertex dynamics models (one for the epithelial monolayer layer and one for the basement membrane and stromal tissue combined) and interactions between the two are considered using the RBMCF to ensure biologically realistic interactions.

Linking Foraging Behaviour and Habitat Preferences During Moult Across Multiple Populations of Red-Throated Diver.

Understanding the habitat use of individuals can facilitate methods to measure the degree to which populations will be affected by potential stressors. Such insights can be hard to garner for marine species that are inaccessible during phases of their annual cycles. Here, we quantify the link between foraging habitat and behaviour in an aquatic bird of high conservation concern, the red-throated diver () across three breeding populations (Finland, Iceland and Scotland) during their understudied moult period.

Discontinuation of SGLT-2i and GLP-1RA among persons with Type 2 diabetes and atherosclerotic cardiovascular disease treated in US cardiology clinics.

SGLT-2i and GLP-1RA are recommended for persons with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD) but are underused in clinical practice. The COORDINATE-Diabetes randomized clincal trial evaluated a multi-faceted intervention to increase the use of evidence-based therapies for reducing cardiovascular risk among participants with diabetes and atherosclerotic cardiovascular disease. This analysis reports the discontinuation rate of SGLT-2i and GLP-1RA in follow up and summarises the clinician-reported reasons underlying these decisions.

Suprachoroidal delivery of viral and non-viral vectors for treatment of retinal and choroidal vascular diseases.

Current treatments for retinal and choroidal neovascular diseases suffer from insufficient durability, including anti-vascular endothelial growth factor-A (VEGF-A) agents. It is, therefore, of interest to explore alternative methods that could allow for robust improvement in visual acuity with fewer injections required. Amongst various pre-clinical and clinical studies in the literature, a promising approach is the use of suprachoroidal injection with viral and non-viral gene delivery vectors.

Biomimetic Anisotropic-Functionalized Platelet-Membrane-Coated Polymeric Particles for Targeted Drug Delivery to Human Breast Cancer Cells.

Biomimetic particles that can replicate aspects of natural biological cell function are useful for advanced biological engineering applications. Engineering such particles requires mimicking the chemical complexity of the surface of biological cells, and this can be achieved by coating synthetic particles with naturally derived cell membranes. Past research has demonstrated the feasibility of utilizing cell membrane coatings from a variety of cell types to achieve extended blood circulation half-life.

Cap-to-bell stage molar tooth morphogenesis occurs through proliferation-independent sulcus sharpening and condensation-associated tension in the dental papilla.

The anatomy of molar teeth is important both functionally for chewing food and in evolutionary studies as a well-preserved species marker in the fossil record. Molar teeth begin to develop their characteristic biting-surface shape of cusps (peaks) and sulci (valleys) at the bell stage, when corresponding folds in the dental epithelium become apparent. Theories about the developmental mechanisms of cusp and sulcus morphogenesis have hitherto largely focused on the non-proliferating nature of the secondary enamel knots (EKs) at the cusp tips.

THE INCLUSION OF SEX AND GENDER IN RESEARCH METHODOLOGY, FUNDING, AND PUBLICATION: A SYSTEMATIC REVIEW.

Importance: Gender inequity in access to and outcomes of orthopaedic care demands research that properly analyses data based on sex and gender. Orthopaedic surgeons have an obligation to mitigate gender inequity in the provision of care by addressing the sex and gender bias in orthopaedic research methodology, grant funding, and publication demonstrated by this review.This study aimed to review the literature on known gender inequities in orthopaedic care, as well as sex and gender bias in orthopaedic research methodology, funding and publication; and to then to outline mitigating strategies.

A Randomized Non-Inferiority Clinical Trial of 14Fr Thal versus 28Fr Tube Thoracostomy for Traumatic Hemothorax.

Background: The traditional treatment of traumatic hemothorax (HTX) is large bore chest tubes (CT) ≥28Fr. Recent evidence shows 14Fr pigtail catheters are as effective in drainage of HTX as larger CT. However, this has not been shown in 14Fr Thal tubes, a straight chest tube placed utilizing Seldinger technique.

Antibiotic Residues in Cattle Reported to Be Raised Without Antibiotics.

In 2019, the U.S. Department of Agriculture's (USDA) Food Safety and Inspection Service (FSIS) provided revised guidance for labeling claims of "raised without antibiotics" (RWA) and similar terms for meat and poultry produced in the US.

Pharmacist-led Si-care (schizophrenia care) model to improve medication adherence and symptom management in schizophrenia.

Introduction: Schizophrenia is a chronic mental disorder that requires long-term treatment, particularly antipsychotic medications. However, medication adherence among patients with schizophrenia is often suboptimal, leading to symptom relapse and poor outcomes. The Si-Care (Schizophrenia Care) program was developed as a pharmacist-led home intervention to improve medication adherence and support symptom control in patients with schizophrenia.

Depth-Based Intervention Detection in the Neonatal Intensive Care Unit Using Vision Transformers.

Depth cameras can provide an effective, noncontact, and privacy-preserving means to monitor patients in the Neonatal Intensive Care Unit (NICU). Clinical interventions and routine care events can disrupt video-based patient monitoring. Automatically detecting these periods can decrease the time required for hand-annotating recordings, which is needed for system development.

Early antibiotic exposure and risk of psychiatric and neurocognitive outcomes: systematic review and meta-analysis.

Background: The prenatal and early-life periods pose a crucial neurodevelopmental window whereby disruptions to the intestinal microbiota and the developing brain may have adverse impacts. As antibiotics affect the human intestinal microbiome, it follows that early-life antibiotic exposure may be associated with later-life psychiatric or neurocognitive outcomes.

Aims: To explore the association between early-life (in utero and early childhood (age 0-2 years)) antibiotic exposure and the subsequent risk of psychiatric and neurocognitive outcomes.

Patient-specific responses to splice-modifying treatments in spinal muscular atrophy fibroblasts.

The availability of three therapies for the neuromuscular disease spinal muscular atrophy (SMA) highlights the need to match patients to the optimal treatment. Two of these treatments (nusinersen and risdiplam) target splicing of , but treatment outcomes vary from patient to patient. An incomplete understanding of the complex interactions among SMA genetics, SMN protein and mRNA levels, and gene-targeting treatments, limits our ability to explain this variability and identify optimal treatment strategies for individual patients.