Reduced incidence of rectal cancer, compared to gastric and colonic cancer, in a population of 73,076 men and women chronically immunosuppressed.

The incidence of gastric, colonic, and rectal cancers was determined in a cohort of 73,076 men and women chronically immunosuppressed after heart or renal transplantation, to test the hypothesis that there would be a reduced incidence of gastric cancer by dampening chronic gastritis secondary to infection caused by Helicobacter pylori. Follow-up was from 1-13 years. No change in the incidence of gastric cancer was found (32 cases observed, 32.

Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation.

In mice, retrovirus-associated breast cancers are promoted by immune mechanisms, and immunosuppression during the premalignant phase reduces the incidence of breast cancer and prolongs life. If some women likewise have immune promotion of breast cancer, the incidence of breast cancer in patients receiving therapeutic immunosuppression should be lower than that in a comparable cohort of non-immunosuppressed women. We examined the incidence of de-novo breast cancer arising in women receiving immunosuppressive therapy after kidney or heart transplantation, comparing the figures with published rates.

Goods handling: tugs, trailers and tractors.

Ease of handling ought to be a priority in any supply and disposal system. Hazel Grayson, senior research officer at the Medical Architecture Research Unit, Polytechnic of North London, suggests that even where driver-operated electric tow tractors cannot be used, other types of electric pulling device should be considered.

Supplies and services: little fish and large pools.

Centralisation of stores and services does not always work smoothly in the NHS and, even when it does, can we be sure that the expected cost advantages will be reaped? Hazel Grayson, senior research officer at the Medical Architecture Research Unit, Polytechnic of North London, discusses some of the questions raised in research carried out by the unit.

Dawson Report: more and smaller theme.

It is possible to consider many of the health centres opened in the last 10 years as 'illness centres' rather than 'health centres'. But Hazel Grayson, research officer, and Dr Raymond Moss, director of the Medical Architecture Research Unit at the Polytechnic of North London, argue that it is where a health centre is, rather than what it is, that determines its success.