Effect of Two Different Penetration Depths of Micro-osteoperforation on the Rate of Orthodontic Tooth Movement: A Prospective Clinical Study.

Objective: The objective is to evaluate the effectiveness of two different penetration depths of micro-osteoperforations (MOPs) on the rate of orthodontic tooth movement over 60 days. In addition, the amount of pain and discomfort caused by the MOP was evaluated.

Materials And Methods: A total of 22 patients (18-30 years) who need fixed orthodontic treatment were recruited and randomly assigned into two groups.

Auxillary aids for pain and anxiety reduction during dental local anesthesia in pediatric patients: a systematic review.

Aims/objectives: This systematic review aimed to evaluate the effectiveness of auxiliary aids-Transcutaneous Electrical Nerve Stimulation (TENS), vibrotactile devices, and Low-Level Laser Therapy (LLLT) in reducing pain and anxiety during dental local anesthesia in pediatric patients.

Methods: The review followed PRISMA guidelines, employing a comprehensive search strategy across multiple databases (PubMed, Cochrane, EBSCO, LILACS, Google Scholar, and Embase) from 2014 to July 2024. Eligibility criteria were based on the PICOS framework, focusing on randomized clinical trials and clinical studies involving pediatric patients undergoing dental procedures with local anesthesia.

Management of Laryngoscope-Induced Iatrogenic Dental Injury: A Case Series.

Dental injury is a common anesthesia-related adverse event, with a high incidence of damage to teeth and surrounding tissues during oro-endotracheal intubation. Poor oral hygiene, compromised periodontium, faulty or loose prosthesis, proclined maxillary incisors along with increased difficulty level of airway management, improper use of laryngoscope, and use of maxillary anterior teeth as a fulcrum for achieving accessibility to the airway are all risk factors for iatrogenic dental injury. This type of injury provides additional physical and psychological trauma to patients who have already undergone medical surgical procedures.

Polygenic Score for Clinicopathologic Features and Survival Outcomes in Papillary Thyroid Carcinoma.

Importance: Genome-wide association studies have identified germline variants associated with the development of papillary thyroid carcinoma (PTC) that can be used to construct a polygenic score (PGS). It is important to determine whether patients with higher germline genetic risk, as summarized using PGS, present with more aggressive disease and/or develop worse clinical outcomes.

Objective: To assess whether germline risk defined by PGS is associated with clinicopathologic features and survival outcomes for patients with PTC.

Two-directional trafficking of the IFT25 protein in the developing mouse sperm flagella.

Intraflagellar transport 25 (IFT25) is a component of the IFT-B complex. In mice, even though this IFT component is not required for cilia formation in somatic cells, it is essential for sperm formation. However, the intracellular localization of this protein in male germ cells is not known given no reliable antibodies are available for histologic studies, and the dynamic trafficking in the developing sperm flagella is not clear.

Comparative evaluation of healing using Er, Cr: YSGG laser treatment with conventional method after extraction of permanent teeth: an in-vivo study.

After dental extractions, patients may experience post-operative pain, with varying degree of severity among patients. The use of Er, Cr: YSGG laser in oral wound healing has garnered considerable interest and attention in recent years. The present study aims to evaluate and assess the wound healing and post operative pain after extraction of teeth in pediatric patients with application of Er, Cr: YSGG laser.

Establishing Diagnostic Reference Levels for Single-Photon Emission Computed Tomography (SPECT) Imaging: A Preliminary Study in Indian Healthcare Settings.

Introduction In nuclear medicine, there is a critical need to balance the control and optimization of radiation doses to ensure patient safety while achieving high-quality diagnostic outcomes. However, diagnostic reference levels (DRLs) for nuclear medicine imaging studies have not been established in India. This study aims to fill this gap by establishing institutional DRLs and assessing radiation dose data specifically for Nuclear Medicine SPECT examinations.

Pioneering technologies over time to rehabilitate crude oil-contaminated ecosystems: a review.

The unremitting pollution of our environment induced by crude oil spillage and drilling site accidents has jeopardized every living species in the biological ecosystem. Removing heavy crude oil constituents with the help of traditional and mainstream oil sorbents because of their ingrained raised viscosities is a strenuous venture. Lighter distillates of crude oil, like condensate, do not aggregate with tremulous shine on the aquatic surface nor settle at the bottom sediment of the water bodies like the heavier components do with time.

Parental acceptance of dental treatment with SDF in children with CP.

Introduction: This study aims to evaluate parental acceptance of dental treatment with silver diamine fluoride (SDF) in children with cerebral palsy (CP).

Methods: The present study is a case-control study with 80 children in the age range of 6-11 years. Group I consisted of children diagnosed with CP and Group II consisted of children without any Special Health Care Needs and systemic conditions.

Exploring Dental Fusion in Primary Dentition: A Pediatric Dental Perspective.

Developmental anomalies of dentition includes abnormalities in teeth size, shape, structure, and number. Dental fusion is one such condition and is one of the most important and frequent developmental dental anomalies that can affect children's oral health. This condition can present various clinical challenges, including aesthetic concerns, occlusal disturbances, and potential impacts on the development and eruption of permanent teeth.

AI-driven innovations in Alzheimer's disease: Integrating early diagnosis, personalized treatment, and prognostic modelling.

Alzheimer's disease (AD) presents a significant challenge in neurodegenerative research and clinical practice due to its complex etiology and progressive nature. The integration of artificial intelligence (AI) into the diagnosis, treatment, and prognostic modelling of AD holds promising potential to transform the landscape of dementia care. This review explores recent advancements in AI applications across various stages of AD management.

Proteomic insights into extracellular matrix dynamics in the intestine of during infection.

Unlabelled: In the aquaculture sector, one of the challenges includes disease outbreaks such as bacterial infections, particularly from (), impacting both wild and farmed fish. In this study, we conducted a proteomic analysis of the intestinal tissue in following infection to elucidate the protein alterations and its implications for immune response. Our findings indicate significant dysregulation in extracellular matrix (ECM)-associated proteins during infection, with increased abundance of elastin and collagen alpha-3(VI).

Challenges faced by dentists during provision of oral health care in children and adolescents with special health-care needs: A scoping review.

Introduction/background: Oral health care for children with special health-care needs (CSHCN) is often overlooked despite a substantial global population with disabilities or special needs. This scoping review delves into the challenges dentists face in delivering oral health care to CSHCN.

Methodology: The scoping review was conducted as per the guidelines of PRISMA-ScR with a search strategy based on the population, intervention, comparison, and outcome (PICO) framework of the research question.

Physiological Responses to Acute Heat Stress in Rohu, Labeo rohita: Insights from Liver Proteomics.

Heat stress is a major problem in aquaculture species, causing changes in physiology such as decreased feed intake, growth rate, reproduction, and internal cellular damage, thereby affecting fish's health. The effects of an acute heat stress simulating a daily rise and fall in temperature on summer days were evaluated in the liver proteome of rohu (Labeo rohita) fingerlings in the present study. The fish maintained at 30 °C were gradually exposed to a higher temperature of 36 °C at an increment rate of 1 °C per 1.

Technological Advancement in Space Management-Prefabricated Space Maintainers: A Case Series.

Unlabelled: Premature loss of primary teeth in children may lead to space loss in the arch, which leads to the collapse of vertical and horizontal occlusal relationships in primary and permanent dentitions. The ideal method to preserve the space in the arch in such a scenario is to use a space maintainer appliance. Conventionally, band and loop space maintainers are the most commonly used space maintainers.

Peripheral immune biomarkers for immune checkpoint inhibition of solid tumours.

Background: With the rapid adoption of immunotherapy for the treatment of cancer comes the pressing need for readily accessible biomarkers to guide immunotherapeutic strategies and offer insights into outcomes with specific treatments. Regular sampling of solid tumour tissues outside of melanoma for immune monitoring is not often feasible; conversely, routine, frequent interrogation of circulating immune biomarkers is entirely possible. As immunotherapies and immune checkpoint inhibitors, in particular, are more widely used in first-line, neoadjuvant, and metastatic settings, the discovery and validation of peripheral immune biomarkers are urgently needed across solid tumour types for improved prediction and prognostication of clinical outcomes in response to immunotherapy, as well as elucidation of mechanistic underpinnings of the intervention.

Engineering the Hot-Spots in Au-Ag Alloy Nanoparticles through Meniscus-Confined 3D Printing for Microplastic Detection.

The escalating concern surrounding microplastic (MP) pollution necessitates urgent attention and the development of rapid techniques for quantifying extremely low concentrations. Surface-enhanced Raman spectroscopy (SERS) has emerged as a promising method due to its simplicity, high sensitivity, and rapid quantification capabilities. Herein, the efficacy of gold-silver alloy nanoparticles (3DPAu-Ag) substrates for detecting poly(methyl methacrylate) (PMMA) and polystyrene (PS) MPs is investigated.

Esthetics in Pediatric Dentistry-BioFlx Crowns: Case Series.

Background: The crown is considered the most effective restoration for the management of dental caries. It reproduces the morphology and contour of the damaged coronal portion of the tooth while maintaining its function. The esthetic needs of children and the demands of parents bring advancement in dentistry toward a new era of esthetic crowns.

A Rare Case Report of Unusual Number of Compound Odontomas in a Pediatric Patient.

Aim: This case report aims to describe the importance of early diagnosis, clinical features, and timely management of multiple odontomas in pediatric patient.

Background: Odontoma is a benign odontogenic tumor of epithelial and mesenchymal origin. Odontomas can occur in multiples and can be associated with other dental anomalies.

Antibacterial, antidiabetic and antioxidant bioevaluation of Griff. and isolation of a flavan type compound.

The plant based natural products have always been a rich source of bioactive molecules for drug discovery. The tender shoots of Griff., an edible medicinal plant was extracted using methanol, water and ethanol as three different solvents to study the effect of the extracting solvents and temperature on their antioxidant, antidiabetic and antibacterial properties and total phenolic and flavonoid contents.

Cell-cultivated aquatic food products: emerging production systems for seafood.

The demand for fish protein continues to increase and currently accounts for 17% of total animal protein consumption by humans. About 90% of marine fish stocks are fished at or above maximum sustainable levels, with aquaculture propagating as one of the fastest growing food sectors to address some of this demand. Cell-cultivated seafood production is an alternative approach to produce nutritionally-complete seafood products to meet the growing demand.

Beyond profit margins: Orchestrating social, economic, and environmental sustainability within the Norwegian Salmon Food Supply Chain.

Food Supply Chains (FSCs) have become increasingly complex with the average distance between producers and consumers rising considerably in the past two decades. Consequently, FSCs are a major source of carbon emissions and reducing transportation costs a major challenge for businesses. To address this, we present a mathematical model to promote the three core dimensions of sustainability (economic, environmental, and social), based on the Mixed-Integer Linear Programming (MILP) method.