Computational Ranking of Yerba Mate Small Molecules Based on Their Predicted Contribution to Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus.

The aqueous extract of yerba mate, a South American tea beverage made from Ilex paraguariensis leaves, has demonstrated bactericidal and inhibitory activity against bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). The gas chromatography-mass spectrometry (GC-MS) analysis of two unique fractions of yerba mate aqueous extract revealed 8 identifiable small molecules in those fractions with antimicrobial activity. For a more comprehensive analysis, a data analysis pipeline was assembled to prioritize compounds for antimicrobial testing against both MRSA and methicillin-sensitive S.

Taxol: efficacy against oral squamous cell carcinoma.

In medicinal chemistry, one of the most studied molecules in recent history is taxol. Taxol is a versatile natural product that is used in various cancer treatment regimens. It is administered to patients with breast, lung, and ovarian cancers, and is currently being studied for the treatment of squamous cell carcinoma of the oral cavity and tongue.

Perioperative supplementation with ascorbic acid does not prevent atrial fibrillation in coronary artery bypass graft patients.

Background: Atrial fibrillation occurs after approximately 25% to 45% of coronary artery bypass graft (CABG) surgeries. Oxidative stress and related electrophysiological remodeling has been proposed as a potential cause of this atrial fibrillation. Perioperative supplementation of the antioxidant ascorbic acid has been evaluated as a preventive agent.

Validation of the World Health Organization Quality of Life HIV instrument in a Zambian sample.

Given the longevity achievable with the current treatment for people living with HIV, quality of life (QOL) has emerged as a significant health outcome measure. The purpose of this study was to test the QOL factor structure in a Zambian sample using the World Health Organization Quality of Life-HIV (WHOQOL-HIV) instrument. A cross-sectional 2 × 2 factorial design was conducted with 160 people living with HIV.

Iron chelators in medicinal applications - chemical equilibrium considerations in pharmaceutical activity.

Iron chelators are being examined as a potential class of pharmaceutical agents to battle different types of cancer as well as iron overload diseases. In recent studies, iron binding species such as desferrioxamine, triapine, tachpyridine, Dp44Mt, and PIH have been tested in cell line tests and clinical trials. Using published chemical equilibrium values (stability constants, equilibrium constants), it is argued that an iron chelator cannot competitively remove iron from a heme-containing biomolecule (i.

The impact of tuberculosis on Zambia and the Zambian nursing workforce.

In Zambia, the incidence of tuberculosis (TB) has greatly increased in the last 10 years. This article describes Zambia and highlights the country's use of the United Nations Millennium Development Goals as a framework to guide TB treatment programmes. An overview of TB in Zambia is provided.

Personnel resource distribution for nursing programs in Carnegie-classified Research I and II and Doctoral I institutions.

Increasingly, nursing education programs, like other major institutions in the United States, are being charged to "do more with less." How to acquire sufficient human and material resources is a continuing challenge in an era of economic constraint. Benchmark data on the distribution of personnel resources within nursing programs is nearly nonexistent.

Pressure ulcer incidence and severity in a community hospital.

In a study of 1320 adult patients admitted to a community hospital, there was a pressure ulcer incidence rate of 8.4%, with 3.2% of pressure ulcers present on admission.

The effect of a support group on grieving individuals' levels of perceived support and stress.

This study examined the effects of support group participation on bereaved individuals' levels of perceived support and stress. Using a single group pretest/posttest design, data were collected from a convenience sample of 21 grieving individuals who participated in 10 weekly support group sessions. Perceived stress decreased significantly (P less than .

Evaluation of a hospital teaching program for breast self-examination.

The purpose of this study was to evaluate the results of a hospital teaching program for breast self-examination. The retention of breast self-examination knowledge and the frequency and accuracy of breast self-examination of 50 subjects 9 months after hospitalization were examined. Findings of the study were that the majority of patients believed they had adequate knowledge to perform breast self-examination following the instructional program and 76% reported performing breast self-examination on a regular basis 9 months post hospitalization.

Assessment and evaluation of pressure sores.

Pressure sore prevention is the desired goal to maintain skin integrity. It is a challenging nursing responsibility. The process of pressure sore prevention requires skilled nursing assessment of the integumentary system and knowledge of risk factors, as well as an ongoing evaluation plan to monitor incidence and the efficacy of nursing care.