Weak fluorescence signals, which are important in research and applications, are often masked by the background. Different amplification techniques are actively investigated. Here, a broadband, geometry-independent and flexible feedback scheme based on the random scattering of dielectric nanoparticles allows the amplification of a fluorescence signal by partial trapping of the radiation within the sample volume.
View Article and Find Full Text PDFHigh-throughput single-cell analysis based on physical properties (such as morphology or mechanics) is emerging as a powerful tool to inform clinical research, with a great potential for translation towards diagnosis. Here we present a novel microfluidic approach adopting acoustic waves to manipulate and mechanically stimulate single cells, and interferometry to track changes in the morphology and measure size, deformability, and refractive index of non-adherent cells. The method is based on the integration within the acoustofluidic channel of a low-finesse Fabry-Perot resonator, providing very high sensitivity and a speed potentially suitable to obtain the high-throughput necessary to handle the variability stemming from the biological diversity of single cells.
View Article and Find Full Text PDFLasers distinguish themselves for the high coherence and high brightness of their radiation, features which have been exploited both in fundamental research and a broad range of technologies. However, emerging applications in the field of imaging, which can benefit from brightness, directionality and efficiency, are impaired by the speckle noise superimposed onto the picture by the interference of coherent scattered fields. We contribute a novel approach to the longstanding efforts in speckle noise reduction by exploiting a new emission regime typical of nanolasers, where low-coherence laser pulses are spontaneously emitted below the laser threshold.
View Article and Find Full Text PDFWe report on an experimental study of photon thermalization and condensation in a semiconductor microresonator in the weak-coupling regime. We measure the dispersion relation of light and the photon mass in a single-wavelength, broad-area resonator. The observed luminescence spectrum is compatible with a room-temperature, thermal-equilibrium distribution.
View Article and Find Full Text PDFNanolasers are considered ideal candidates for communications and data processing at the chip-level thanks to their extremely reduced footprint, low thermal load and potentially outstanding modulation bandwidth, which in some cases has been numerically estimated to exceed hundreds of GHz. The few experimental implementations reported to date, however, have so-far fallen very short of such predictions, whether because of technical difficulties or of overoptimistic numerical results. We propose a methodology to study the physical characteristics which determine the system's robustness and apply it to a general model, using numerical simulations of large-signal modulation.
View Article and Find Full Text PDFStarting from a fully quantized Hamiltonian for an ensemble of identical emitters coupled to the modes of an optical cavity, we determine analytically regimes of thermal, collective anti-bunching and laser emission that depend explicitly on the number of emitters. The lasing regime is reached for a number of emitters above a critical number-which depends on the light-matter coupling, detuning, and the dissipation rates-via a universal transition from thermal emission to collective anti-bunching to lasing as the pump increases. Cases where the second order intensity correlation fails to predict laser action are also presented.
View Article and Find Full Text PDFA low-cost device for registration-free quantitative phase microscopy (QPM) based on the transport of intensity equation of cells in continuous flow is presented. The method uses acoustic focusing to align cells into a single plane where all cells move at a constant speed. The acoustic focusing plane is tilted with respect to the microscope's focal plane in order to obtain cell images at multiple focal positions.
View Article and Find Full Text PDFThe classical description of laser field buildup, based on time-averaged photon statistics of Class A lasers, rests on a statistical mixture of coherent and incoherent photons. Here, applying multiple analysis techniques to temporal streams of data acquired in the threshold region of a Class B mesoscale laser, we conclusively show that new physics is involved in the transition: the lasing buildup is controlled by large dynamical spikes, whose number increases as the pump is raised, evolving into an average coherent field, modulated by population dynamics, and eventually relaxing to a steady state for sufficiently large photon numbers. These results explain inconsistencies observed in small scale devices.
View Article and Find Full Text PDFWe report on a high-resolution double-channel imaging method used to synchronously map the intensity- and optical-frequency-distribution of a laser beam in the plane orthogonal to the propagation direction. The synchronous measurement allows us to show that the laser frequency is an inhomogeneous distribution below threshold, but that it becomes homogeneous across the fundamental Gaussian mode above threshold. The beam's tails deviations from the Gaussian shape, however, are accompanied by sizeable fluctuations in the laser wavelength, possibly deriving from manufacturing details and from the influence of spontaneous emission in the very low intensity wings.
View Article and Find Full Text PDFA Stochastic Simulator (SS) is proposed, based on a semiclassical description of the radiation-matter interaction, to obtain an efficient description of the lasing transition for devices ranging from the nanolaser to the traditional "macroscopic" laser. Steady-state predictions obtained with the SS agree both with more traditional laser modeling and with the description of phase transitions in small-sized systems, and provide additional information on fluctuations. Dynamical information can easily be obtained, with good computing time efficiency, which convincingly highlights the role of fluctuations at threshold.
View Article and Find Full Text PDFFor many years, the apparent absence of a phase instability has characterized lasers as peculiar nonlinear oscillators. We show that this unusual feature is solely due to the approximations used in writing the standard models. A new, careful derivation of the fundamental equations, based on codimension 2 bifurcation theory, shows the possible existence of dynamical regimes displaying either a pure phase instability, or mixed phase-amplitude turbulence.
View Article and Find Full Text PDFThe response of a Class B laser to a rapid change in one of its parameters is known to be accompanied by delay and ringing. It has been theoretically and numerically shown that the transition can be modified by using adequate functional shapes for the control parameter (e.g.
View Article and Find Full Text PDFThe standard model introduced to describe the collective atomic recoil of an ensemble of atoms interacting with a strong electromagnetic field has been here extended by the inclusion of collisions with a buffer gas. As a result, we find that in the thermodynamic limit the coherent emission of radiation exhibits a continuous phase transition upon increasing the pump intensity. The output laser field is strictly larger than 0 only above a critical value.
View Article and Find Full Text PDFWe show that the transition between fixed points in a separable dynamical system is fully described by an invariant integral. We discuss in detail the case of a system with two temporal variables with bilinear coupling, where the new stable state is attained asymptotically through spiraling into the fixed point. Through the invariance, it is possible to establish conditions for the control parameter that permit a (targeted) transition in finite time and without relaxation oscillations.
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