[Common history and prospects in surgical gynecology of the Charité and the Vienna University Clinic].

In a review, the historical connections between the medical centers of the University of Berlin (Charité) and the University of Vienna are described. The present status is reported and several suggestions for a further development are given.

The management in ovarian cancer at the First Dept. of Obstetrics and Gynecology, University of Vienna.

The evolution in the management of ovarian cancer at the First Department of Obstetrics and Gynecology of Vienna University is reviewed. The improvement in radical surgery and a more rational application of adjuvant treatment modalities produced a relative improvement in 5 year survival in the last period under review.

Surgical management of vesicovaginal fistulas according to Chassar Moir's method.

Aside from the more common perioperative and postoperative dysfunctions of micturition, urogenital fistulas represent the most frequent complication encountered after surgical gynecologic interventions. Vesicovaginal fistulas are the most common communication between efferent urinary passages and the genital tract. From 1967 to 1987, 42 women had a vesicovaginal fistula develop after abdominal or vaginal operations and underwent another operation.

[Surgical correction of vesicovaginal fistulas with the Chassar Moir method].

Besides a relatively high frequency of perioperative and postoperative dysfunctions of micturition, urogenital fistulae are the most frequent complication occurring after surgical gynaecological interventions. Vesico-vaginal fistulae are the most common communication between the efferent urinary passages and the genital tract. From 1967 to 1987, 42 women who had developed a vesico-vaginal fistula after abdominal or vaginal surgery or irradiation were operated on again.

Reliability of in-situ hybridization of smears and biopsies for papilloma virus genotyping of the uterine cervix.

Two sampling methods, biopsy and cell smear, were investigated for their reliability in the biotin in-situ hybridization test for human papilloma virus deoxyribonucleic acid (HPV-DNA)-6/11 and 16/18. Cervical smears and biopsies were obtained simultaneously from 81 women with cervical lesions. The sensitivity of the in-situ hybridization was tested on human cervical carcinoma cell lines.

[Historical development of the Radiology Department of the 1st and 2d University Women's Hospital Vienna].

A historical review is given on the installation of the Department of Radiotherapy of the 1st Department of Obstetrics and Gynecology and its further development to the Department of Irradiation of the 1st and 2nd Department of Obstetrics and Gynecology at the Vienna University. The milestones of the last 40 years like the change to the "New Stockholm Method" (1954), the new construction and adaptation (1968-1972) with the installation of a telecobalt-therapy-unit (1972), the conjunction of the department of radiotherapy of both university departments to a single department in the same year and finally the introduction of the after-loading method in brachytherapy (1980) are pointed out specifically.

Various effects of abdominal and vaginal hysterectomy in benign diseases.

The relative advantages and disadvantages of the transabdominal versus the transvaginal approach to hysterectomy were evaluated and the two procedures were compared for differences in hospitalization, patient age, bowel activity and operating time on the basis of a material of 94 hysterectomized patients. Intestinal complications such as subileus were noted only in subjects who were treated by abdominal hysterectomy. This corresponded with the significant decrease in potassium in abdominally operated patients on the second post-surgical day.

[Repair of vesico-vaginal fistulas using the Chassar Moir method].

Besides the relatively frequent perioperative and postoperative dysfunctions of micturition, urogenital fistulae are the most frequent complication occurring after surgical gynaecologic interventions. Vesico-vaginal fistulae are the most common communication between efferent urinary passages and genital tract. From 1969 to 1986, 36 women developed a vesico-vaginal fistula after abdominal or vaginal surgery and were operated on again.

First experiences with intraperitoneal chemotherapy in ovarian cancer.

The Authors report their experience with intraperitoneal chemotherapy in post surgical management of ovarian cancer. 24 patients were evaluable for the study and the results indicate that in patients with bulky disease the complication rate was high and the therapeutical outcome very poor. Only in patients with microscopic disease and residual tumor smaller than 2 cm seemed to benefit from intraperitoneal chemotherapy.

Diagnostic and intraoperative immunoscintigraphy in ovarian cancer.

A new strategy for tumor detection using immunoscintigraphic techniques was used in an attempt to improve the diagnostic potential of conventional external immunoscintigraphy. Twelve patients who were strongly suspected to either suffer from primary or recurrent ovarian cancer were investigated as follows: radioimmuno-scintigraphy (RIS) by means of radiolabelled antibodies was performed in all patients prior to operation (first or second look). During the operative procedure, which always took place immediately after completion of the diagnostic RIS, a hand-held gamma-ray detection probe, especially developed for this purpose was used for the purpose of identifying radiolabelled tumor sites intra-operatively in the open abdomen.

[Results of radical radioisotope surgery of cervix cancer].

During the period 1970-1981 radioisotope radical surgery was performed in 270 patients suffering from cervical carcinoma stage Ib und II. During the development of the method, which has a three-stage process, the rate of cases with complete lymphadenectomy was increased from 52.5% to 75.

Radio-immunoscintigraphy and intraoperative tumour detection by means of anti-tumour antibodies in patients with ovarian cancer.

A hand-held gamma-ray detection probe was developed by us to circumvent the problems of conventional radio-immunoscintigraphy (RIS). The intraoperative use of this probe in terms of radionuclide-assisted surgery (RAS) should help to overcome problems associated with insufficient accumulation by the tumour of the radio-active antibodies, unfavourable localization of tumour sites, collimation problems, etc., in patients with ovarian cancer.

[Immunoscintigraphy and intraoperative tumor search in ovarian cancer].

The diagnostic possibilities of immunoscintigraphy (IS) in ovarian cancer are discussed. Seventy-five patients were investigated by IS using the radioantibodies HMFG-2 (n = 63) or OC-125 (n = 12). The results showed a specificity of 75%, sensitivity of 87%, and accuracy of 84%.

[Schauta-Amreich expanded total vaginal excision in cervix cancer in relation to historical development].

After a historical outlook on the development of radical vaginal hysterectomy, our own results and complications in 51 cases of stages I and II during the years 1968-1983 are reported. The 5-year survival rate was 98.04% with no primary mortality.

Radionuclide-guided radical surgery for cervical cancer.

Radio-isotope radical operation has been developed in three steps. The rate of complete lymphadenectomies determined by the complete removal of labelled tissue was increased from 52.2% in the first observation period to 67.

[Serum proteins in vaginal and abdominal hysterectomy].

Postoperative changes in various acute-phase-proteins (alpha 1-antitrypsin, c-reactive protein), alpha 2-macroglobulin, haptoglobin, transferrin, c3-c4-complement and myoglobin as well as four endocrine parameters (TBG, SHBG, prolactin and cortisol) were studied in forty healthy women divided into two groups. Each group consisted of 20 women who underwent either vaginal or abdominal hysterectomy. Differences between both groups related to both operative methods, seen in determination of 2-acute-phase-proteins, alpha 1-antithrypsin, CRP and the muscle specific myoglobin where established, whereby no statistically significant differences were apparent concerning the other parameters and hormones.

[Serum proteins and hormones in vaginal and abdominal hysterectomy].

Postoperative changes in various acute-phase-proteins (alpha 1-Antitrypsin, c-reactive protein), alpha 2-Macroglobulin, haptoglobin, transferrin. c3-c4-complement and myoglobin as well as endocrine parameters were studied in forty healthy women in two groups. Women with malignant neoplasms were excluded.

[Incidence of hyperandrogenemia].

Within two years 341 amenorrheic patients treated in our endocrinological outpatient department were listed up retrospectively in WHO-classification groups. In 30 patients a primary amenorrhea and in 311 patients a secondary amenorrhea could be registered. In 28.