A new class of penicillin-binding protein inhibitors to address drug-resistant .

β-Lactams are the most widely used antibiotics for the treatment of bacterial infections because of their proven track record of safety and efficacy. However, susceptibility to β-lactam antibiotics is continually eroded by resistance mechanisms. Emerging multidrug-resistant (MDR) strains possessing altered alleles (encoding PBP2) pose a global health emergency as they threaten the utility of ceftriaxone, the last remaining outpatient antibiotic.

Cardiovascular Safety of Testosterone-Replacement Therapy.

Background: The cardiovascular safety of testosterone-replacement therapy in middle-aged and older men with hypogonadism has not been determined.

Methods: In a multicenter, randomized, double-blind, placebo-controlled, noninferiority trial, we enrolled 5246 men 45 to 80 years of age who had preexisting or a high risk of cardiovascular disease and who reported symptoms of hypogonadism and had two fasting testosterone levels of less than 300 ng per deciliter. Patients were randomly assigned to receive daily transdermal 1.

Smartphone-Based Optical Fiber Fluorescence Temperature Sensor.

Optical fiber sensors are one preferred solution for temperature sensing, especially for their capability of real-time monitoring and remote detection. However, many of them still suffer from a huge sensing system and complicated signal demodulate process. In order to solve these problems, we propose a smartphone-based optical fiber fluorescence temperature sensor.

3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body.

Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. We have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the bloodstream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The support structure of the absorbers was built using 3D printing technology.

Disparities and Trends in Door-to-Needle Time: The FL-PR CReSD Study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities).

Background And Purpose: In the United States, about half of acute ischemic stroke patients treated with tPA (tissue-type plasminogen activator) receive treatment within 60 minutes of hospital arrival. We aimed to determine the proportion of patients receiving tPA within 60 minutes (door-to-needle time [DTNT] ≤60) and 45 minutes (DTNT ≤45) of hospital arrival by race/ethnicity and sex and to identify temporal trends in DTNT ≤60 and DTNT ≤45.

Methods: Among 65 654 acute ischemic stroke admissions in the National Institute of Neurological Disorders and Stroke-funded FL-PR CReSD study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities) from 2010 to 2015, we included 6181 intravenous tPA-treated cases (9.

Ethylcellulose Colloids Incubated in Dilute Solution.

This study revealed, for the first time, that dilute solutions made of a representative series of commercial ethylcellulose (EC; molecular weights 77-305 kDa, provided by the manufacturer) and four distinct organic solvents (α-terpineol, 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (TPIB), tetrahydrofuran (THF), and benzene) can be used to foster stabilized, nearly monodisperse, nanoscale (pure) polymer colloid, with no isolated chains present. Using combined light-scattering (dynamic light scattering, static form factor, and Zimm/Berry plots) and intrinsic viscosity (Tanglertpaibul-Rao, Huggins, and Kraemer plots) analyses, the structural features of colloidal EC aggregates, ρ = ⟨R⟩/⟨R⟩ = 0.67-0.

Determination of cobalt in low-alloy steels using laser-induced breakdown spectroscopy combined with laser-induced fluorescence.

Cobalt element plays an important role for the properties of magnetism and thermology in steels. In this work, laser-induced breakdown spectroscopy combined with laser-induced fluorescence (LIBS-LIF) was studied to selectively enhance the intensities of Co lines. Two states of Co atoms were resonantly excited by a wavelength-tunable laser.