Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease.

Modulating immune function is a critical strategy in cancer and atherosclerosis treatments. For cancer, boosting or maintaining the immune system is crucial to prevent tumor growth. However, in vascular disease, mitigating immune responses can decrease inflammation and slow atherosclerosis progression.

Transforming an ATP-dependent enzyme into a dissipative, self-assembling system.

Nucleoside triphosphate (NTP)-dependent protein assemblies such as microtubules and actin filaments have inspired the development of diverse chemically fueled molecular machines and active materials but their functional sophistication has yet to be matched by design. Given this challenge, we asked whether it is possible to transform a natural adenosine 5'-triphosphate (ATP)-dependent enzyme into a dissipative self-assembling system, thereby altering the structural and functional mode in which chemical energy is used. Here we report that FtsH (filamentous temperature-sensitive protease H), a hexameric ATPase involved in membrane protein degradation, can be readily engineered to form one-dimensional helical nanotubes.

Association analysis of genetic polymorphisms of METTL3 with clinical outcomes in a Chinese pediatric population with primary brain tumors.

Background: Methyltransferase-like 3 (METTL3) regulates numerous biological processes and diverse cancers.

Objective: To explore the frequency distribution of METTL3 rs1061026, rs1139130, and rs1263801 polymorphisms, and their potential impacts on clinical outcomes and chemotherapy-induced toxicities in a cohort of Chinese pediatric patients diagnosed with primary brain tumors (PBTs).

Methods: Genotyping for three investigated SNPs was performed in 107 pediatric patients with PBTs using the Sequenom MassARRAY iPLEX platform.

Construction of efficient ethylene removal and antibacterial cellulose paper-based packaging materials for avocado preservation.

Fruits are susceptible to ethylene ripening and microbial infestation, which can lead to spoilage and further significant economic losses. Thus, using functional preservation materials is an effective controlling technology to improve the post-harvest quality and extend the shelf life of fruits. Hence, a dual-function cellulose-based paper with exceptional antibacterial efficiency, favourable ethylene removal performance, improved mechanical and hydrophobic properties was prepared by covalently grafted antibacterial guanidine salt and surface-modified ethylene scavenger.

CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells.

Clinical application of autologous chimeric antigen receptor (CAR)-T cells is complicated by limited targeting of cancer types, as well as the time-consuming and costly manufacturing process. We develop CD70-targeted, induced pluripotent stem cell-derived CAR-natural killer (NK) (70CAR-iNK) cells as an approach for universal immune cell therapy. Besides the CD70-targeted CAR molecule, 70CAR-iNK cells are modified with CD70 gene knockout, a high-affinity non-cleavable CD16 (hnCD16), and an interleukin (IL)-15 receptor α/IL-15 fusion protein (IL15RF).

Aqueous Binder with Self-Emulsifying Characteristics for Practical Si/C Anode in Lithium-Ion Batteries.

Silicon/carbon (Si/C) materials have achieved commercial applications as a solution to the problems of large volume expansion and short lifespan of silicon-based anodes in lithium-ion batteries. However, the potential risk of structural fracture and localized differences in surface adsorption properties lead to difficulties in maintaining the structural integrity of Si/C anodes using conventional binders during repeated lithiation/delithiation. Herein, an aqueous binder (PVA-g-M) based on polyvinyl alcohol (PVA) grafted methacrylic acid (MAA) obtained by self-emulsifyingemulsion polymerization is reported.

In situ growth of defective ZIF-8 on TEMPO-oxidized cellulose nanofibrils for rapid response release of curcumin in food preservation.

Uncontrolled release of active agents in active packaging reduces antimicrobial efficacy, hindering the effective protection of perishable products from microbial infection. Herein, a novel defective engineering was proposed to design defective and hollow ZIF-8 structures grown on TEMPO oxidized cellulose nanofibrils (TOCNFs) and use them as fast-reacting nanocarriers for loading and controlled release curcumin (Cur) in sodium alginate (SA) active packaging systems (CZT-Cur-SA). By employing stable chelation between tannic acid (TA) and ZIF-8 zinc ions, the connections between zinc ions and imidazole ligands were severed to form a loose and hollow structure, which facilitates the rapid reaction and release of active ingredients triggered by pH changes in the microenvironment.

NPA7: A Dual Receptor Activating Peptide That Inhibits Cardiac Oxidative Stress.

Background: Cardiomyocyte oxidative stress significantly contributes to the progression of hypertension-induced heart failure, highlighting the need for targeted therapies. We developed a novel peptide, NPA7, that coactivates the GC-A (guanylyl cyclase A)/cGMP and MasR (Mas receptor)/cAMP pathway. This study aimed to test NPA7's ability to inhibit oxidative stress by modulating the p62-KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor erythroid 2-related factor 2) pathway in human cardiomyocytes (HCMs) and a rat model of hypertension.

High-Density Polyethylene Janus Fibrous Membrane with Enhanced Breathability and Moisture Permeability via PDA Assisted Hydrophilic Modification.

Functional fibrous membranes with high mechanical properties are intensively developed for different application fields. In this study, to enhance moisture and air permeability without compromising mechanical strength, a facile float-surface modification strategy is employed to fabricate Janus fibrous membranes with distinct hydrophobicity/hydrophilicity using the high-density polyethylene (HDPE) fibrous membranes. By coating one side of the HDPE fibrous membranes with polydopamine (PDA) and a superhydrophilic polyelectrolyte, the obtained Janus HDPE fibrous membranes demonstrate an excellent water transmission rate (577.

[Influence of Methylenetetrahydrofolate Reductase Polymorphism on High-Dose Methotrexate Toxicity in Pediatric Mature B-cell lymphoma Patients].

Objective: To investigate the effect of genetic polymorphism of (rs1801133) on methotrexate (MTX) related toxicity in pediatric mature B-cell lymphoma patients.

Methods: Fifty-eight intermediate and high risk patients under 18 years of age with mature B-cell lymphoma who received 5 g/m MTX (24 h intravenous infusion) in Sun Yat-sen University Cancer Center from August 2014 to December 2021 were included, and their toxicity of high-dose MTX (HD-MTX) were monitored and analyzed.

Results: Among the 58 pediatric patients, the number of CC, CT, and TT genotypes for was 33, 19 and 6, respectively.

Assessment of grazing livestock balance on the Eastern Mongolian Plateau based on remote sensing monitoring and grassland carrying capacity evaluation.

Rational utilization of natural resources is crucial in arid and semi-arid areas due to their vulnerable ecosystems and low resource resilience. Achieving a balance between grassland production and livestock grazing, known as the pasture-livestock balance, is essential for the sustainable development of grassland resources on the Mongolian Plateau (MP). This study focuses on the grassland regions of 8 provinces in eastern Mongolia (MNG) and 7 leagues in Inner Mongolia (IMNG), China, during the period from 2018 to 2022.

Effects of nitrogen deposition on soil nitrogen fractions and enzyme activities in wet meadow of the Qinghai-Tibet Plateau.

Soil nitrogen (N) transformation is an essential portion of the N cycle in wetland ecosystems, governing the retention status of soil N by controlling the effective soil N content. N deposition produced by human activities changes the physical characteristics of soil, affecting N fractions and enzyme activities. To characterize these influences, three different N addition levels (N5, 5 g/m; N10, 10 g/m; N15, 15 g/m) were established using a wet meadow on the Qinghai-Tibet Plateau (QTP) as a control treatment (0 g/m).

Geographic and socioeconomic disparities in mortality burden attributable to long-term exposure to NO across 231 cities in China from 2015 to 2019.

Research on geographic and socioeconomic disparities of NO attributed mortality burden is limited. This study aims to quantify the geographic and socioeconomic differences in the association between long-term exposure to NO and mortality burden in China. We estimated the all-cause mortality burden of adults over 16 years old attributable to NO exposure above 10 µg/m for 231 Chinese cities from 2015 to 2019, and geographic and socioeconomic differences .

Enhancing astaxanthin accumulation in immobilized Haematococcus pluvialis via alginate hydrogel membrane.

Immobilized cultivation is anticipated to be effective for enhancing both biomass and astaxanthin accumulation in Haematococcus pluvialis (H. pluvialis). A novel fabrication method of alginate hydrogel membrane (AHM) was introduced for immobilized cultivation of H.

Making Accessible and Attractive Porosities in Block Copolymer Nanofibers for Highly Permeable and Durable Air Filtration.

Submicron particulate matter (PM) can penetrate deeply into human tissue, posing a serious threat to human health. However, the electrostatic charge of commercial respirators is easily dissipated, making it difficult to maintain long-term filtration. Herein, a hierarchically porous filter based on nanofibers with accessible porosity and particulate-attractive surfaces, achieving significant filtration performance is developed through polarity-driven interactions.

[Spatiotemporal Patterns and Driving Forces Analysis of Ecological Carbon Sink from 2001 to 2022 in Qinling-Daba Mountains,China].

The Qinling-Daba Mountain area, an essential ecological conservation zone in China, occupies a pivotal position in the pursuit of carbon neutrality. Using diverse data sources, including temperature, precipitation, solar radiation, and the Normalized Difference Vegetation Index, we refined the CASA model by replacing model indicators. This enhanced model simulated the net primary productivity of vegetation in the Qinling-Daba Mountain area from 2001 to 2022.

[Quantitative Analysis of the Drivers of the Spatio-temporal Evolution of Vegetation NPP in the Beijing-Tianjin-Hebei Ecological Barrier Area].

The Taihangshan-Yanshan Region is an important ecological barrier area in Beijing-Tianjin-Hebei, and it is of great importance to investigate the spatial distribution pattern and driving mechanism of net primary productivity （NPP） of vegetation for ecological restoration. The MOD17A3HGF.061 NPP dataset was obtained using the Google earth engine（GEE）, and Sen trend, coefficient of variation, partial correlation, complex correlation, and residual analysis were applied to investigate the spatial and temporal patterns of vegetation NPP in the study area and to quantitatively isolate the relative contributions of climate change and human activities.

Development and evaluation of pH-sensitive Euryale ferox starch-based films containing nano-SiO and Chinese rose (Rosa chinensis) extract for freshness monitoring of chicken breast meat.

In this study, smart films of EFS, EFS-SiO and EFS-SiO-CRE were successfully developed by using Euryale ferox starch (EFS), nano-SiO and Chinese rose extract (CRE). The Chinese rose flower had a high content of anthocyanins (1.73 mg/g) and CRE exhibited different colors in varying pH buffers (2-13).

Response of South Asia PM pollution to ammonia emission changes and associated impacts on human health.

Countries in South Asia are suffering severe PM pollution with rapid economic development, impacting human health and the environment. Whilst much attention has been given to understanding the contribution of primary emissions, the contribution of agriculture to PM concentrations, especially from agricultural ammonia (NH) emissions, remains less explored. Using an advanced regional atmospheric chemistry and transport modelling system (WRF-EMEP) with a new estimate of anthropogenic NH emissions inputs, we estimate the influence of agricultural NH emissions on surface PM in South Asia and evaluate the health impacts and the economic losses attributable to PM in 2018.

Unlocking vegetation health: optimizing GEDI data for accurate chlorophyll content estimation.

Chlorophyll content is a vital indicator for evaluating vegetation health and estimating productivity. This study addresses the issue of Global Ecosystem Dynamics Investigation (GEDI) data discreteness and explores its potential in estimating chlorophyll content. This study used the empirical Bayesian Kriging regression prediction (EBKRP) method to obtain the continuous distribution of GEDI spot parameters in an unknown space.

Addition of SHR-1701 to first-line capecitabine and oxaliplatin (XELOX) plus bevacizumab for unresectable metastatic colorectal cancer.

This phase 2/3 trial (NCT04856787) assessed the efficacy and safety of SHR-1701, a bifunctional protein targeting PD-L1 and TGF-β, in combination with BP102 (a bevacizumab biosimilar) and XELOX (capecitabine plus oxaliplatin) as a first-line treatment for unresectable metastatic colorectal cancer (mCRC). In this phase 2 study, a total of 62 patients with untreated, histologically confirmed colorectal adenocarcinoma and no prior systemic therapy for metastatic disease were enrolled. Patients received SHR-1701 (30 mg/kg), bevacizumab (7.

Chemical characterization and source identification of PM in the Huaxi urban area of Guiyang.

In 2020, 123 PM samples were collected across different seasons in Huaxi District, Guiyang. The primary chemical components of PM, including water-soluble ions (WSIIs), metallic elements, organic carbon (OC), and elemental carbon (EC), were analyzed. During the sampling period, the average PM concentration was 39.

Construction of a physical map for Aegilops geniculata chromosome 7M and localization of its novel purple coleoptile gene.

A physical map of Aegilops geniculata chromosome 7M was constructed, and a novel purple coleoptile gene was localized at 7MS bin FL 0.60-0.65 by development of wheat-Ae.