Isolation and characterization of a newly identified Clostridium butyricum strain SCUT343-4 for 1,3-propanediol production.

A novel 1,3-propanediol (1,3-PDO) producing strain was isolated and identified as Clostridium butyricum with respect to its morphological and physiological characteristics, as well as 16S rDNA. The results of substrates test and stress tolerance indicated that C. butyricum SCUT343-4 could produce 1,3-PDO efficiently from glycerol.

Biomarker-based score for predicting in-hospital mortality of children admitted to the intensive care unit.

This study aims to establish a new scoring system based on biomarkers for predicting in-hospital mortality of children admitted to the pediatric intensive care unit (PICU). The biomarkers were chosen using the least absolute shrinkage and selection operator (LASSO)-logistic regression in this observational case-control study. The performance of the new predictive model was evaluated by the area under the receiver operating characteristic curve (AUC).

Kidney re-transplantation after living donor graft nephrectomy due to chromophobe renal cell carcinoma: A case report.

Background: There are few reported cases of allograft nephrectomy due to malignancy followed by successful renal re-transplantation two years later. In this paper, we report a patient who underwent kidney re-transplantation after living donor graft nephrectomy due to chromophobe renal cell carcinoma (ChRCC) involving the allograft kidney.

Case Summary: A 34-year-old man underwent living kidney transplantation at the age of 22 years for end-stage renal disease.

Synthesis of polyoxometalates (POM)/TiO/Cu and removal of nitrate nitrogen in water by photocatalysis.

Nitrate nitrogen is one of the vital issues needed to be addressed in the water purification process utilizing groundwater as a drinking water source. In this study, a sandwich-type polyoxometalate Na [α-SiWO] has been synthesized and SiW/TiO/Cu composite has been prepared by sol-gel method. Samples have been characterized by XRD, BET, FTIR, SEM, ED-Mapping, UV-Vis, XPS.

Graphene-Reinforced Zn-Ni Alloy Composite Coating on Iron Substrates by Pulsed Reverse Electrodeposition and Its High Corrosion Resistance.

In this paper, a novel kind of graphene (Gr)-reinforced Zn-Ni alloy composite coating is successfully prepared on an iron substrate by pulsed reverse electrodeposition. Hydrophilic graphene oxide (GO) is directly added to the electrolyte and reduced to Gr during coating. The experimental results reveal that (1) there is an optimal adding amount (about 0.

Malignant plasmacytes in bone marrow detected by flow cytometry as a predictor for the risk stratification system of multiple myeloma.

Background: Multiple myeloma (MM) is a clonal disorder characterized by the proliferation of plasma cells and their accumulation within the bone marrow (BM). The flow cytometric analysis is an essential method for the hematological diseases because of high sensitivity.

Aims: This study evaluates the indication role of malignant plasmacytes (PCs) in BM detected by flow cytometry for the risk stratification of MM.

Herbal Medicine "Shulifenxiao" Formula for Nephrotic Syndrome of Refractory Idiopathic Membranous Nephropathy.

Treatment for adult patients with refractory idiopathic membranous nephropathy (RIMN) by conventional immunosuppressive regimens is not satisfactory. This study aims to evaluate the effectiveness of Chinese herbal medicine, Shulifenxiao formula, as a promising regimen. A total of 31 RIMN patients resistant to corticosteroid or immunosuppressive agents were retrospectively analyzed.

Butanol production from Saccharina japonica hydrolysate by engineered Clostridium tyrobutyricum: The effects of pretreatment method and heat shock protein overexpression.

Macroalgal biomass is currently considered as a potential candidate for biofuel production. In this study, the effects of pretreatment method and heat shock protein overexpression were investigated for efficient butanol production from Saccharina japonica using engineered Clostridium tyrobutyricum. First, various pretreatment methods including acid hydrolysis, acid hydrolysis and enzymatic saccharification, and ultrasonic-assisted acid hydrolysis were employed to obtain the fermentable sugars, and the resulted hydrolysates were evaluated for butanol fermentation.

Magnetic cotton textile wastes pyrolyzed by ferric cerium oxide for degradation of p-nitrophenol by catalytic ozonation.

In this paper, magnetic cotton textile wastes pyrolyzed by ferric cerium oxide (FeCe oxide/PC) were synthesized for degradation of p-nitrophenol by catalytic ozonation, and the optimal Fe-Ce ratio was 10:1. Compared to FeCe oxide, the FeCe oxide/PC not only greatly improved the degradation efficiency of PNP, but also reduced the dosage of catalyst. Through the BET test, the FeCe oxide/PC has a high specific surface area to absorb part of the pollutants.

Effective removal of refractory organic contaminants from reverse osmosis concentrated leachate using PFS-nZVI/PMS/O process.

Reverse osmosis concentrated leachate (ROCL) from landfill leachate treatment contains high amounts of refractory organics. In this study, a combination of polymerized ferric sulfate (PFS) and nanoscale zero-valent iron/peroxymonosulfate/ozone (nZVI/PMS/O) approach was adopted to remove refractory pollutants in ROCL. The effects of coagulant species, dosage and initial pH on the pre-treatment of organics from ROCL during coagulation process were investigated.

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.

Effective therapeutics are urgently needed to counter infection and improve outcomes for patients suffering from COVID-19 and to combat this pandemic. Manipulation of epigenetic machinery to influence viral infectivity of host cells is a relatively unexplored area. The bromodomain and extraterminal (BET) family of epigenetic readers have been reported to modulate SARS-CoV-2 infection.

Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models.

Emergency use authorization of COVID vaccines has brought hope to mitigate pandemic of coronavirus disease 2019 (COVID-19). However, there remains a need for additional effective vaccines to meet the global demand and address the potential new viral variants. mRNA technologies offer an expeditious path alternative to traditional vaccine approaches.

Aged microplastics decrease the bioavailability of coexisting heavy metals to microalga Chlorella vulgaris.

Environmental aging of ubiquitous microplastics (MP) occurs through the action of biotic and abiotic factors, and aged MP exhibit different physicochemical properties and environmental behavior from virgin MP. This study aimed to investigate the aged micro-sized polystyrene (mPS) and polyvinyl chloride (mPVC), and the heavy metals copper (Cu) and cadmium (Cd), and examine the effects of their combined toxicities on microalga Chlorella vulgaris. Results showed that the presence of MP inhibited cell growth as compared with the control, the inhibition rate (I) decreased as concentrations of MP rose and aged MP exhibited stronger inhibition of cells than did virgin MP.

High CFP score indicates poor prognosis and chemoradiotherapy response in LARC patients.

Background: Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis and tumor response in locally advanced rectal cancer (LARC) patients. This study aims to explore the prognostic and predictive role of carcinoembryonic antigen (CEA), the Fibrinogen-Albumin Ratio Index (FARI), the Prognostic Nutritional Index (PNI) in LARC patients and compared them with a novel combined CEA-FARI-PNI (CFP) scoring system.

Methods: A total of 138 LARC patients undergoing radical surgery following neoadjuvant chemoradiotherapy (NCRT) between January 2012 and March 2019 were enrolled.

Hydrometallurgical enhanced liberation and recovery of anode material from spent lithium-ion batteries.

The efficient recycling of spent anode material (SAM) from spent lithium-ion batteries (LIBs) is generally critical in terms of electronic waste recyclingas well as increasing resource shortage and environmental problems. This research reported a novel and green method to recycle lithium, copper foil, and graphite from SAM by water leaching treatment. The results indicated that 100% of graphite was exfoliated from the anode material and 92.

BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be through direct cardiac infection and/or inflammation-induced dysfunction. To identify mechanisms and cardio-protective drugs, we use a state-of-the-art pipeline combining human cardiac organoids with phosphoproteomics and single nuclei RNA sequencing.

Transcriptomic and metabolomic profiling of a Rhodotorula color mutant to improve its lipid productivity in fed-batch fermentation.

Lipids produced by oleaginous microorganisms enrich the supply of feedstock for bio-fuel. In this study, a mutant (Mut) obtained by UV-nitrosoguanidine mutagenesis turned its colony color from orange-red to light-yellow and showed higher lipid productivity at 37 °C than the original strain Rhodotorula sp. U13N3 (Rht) in the glycerol medium.

Recovering heavy metals from electroplating wastewater and their conversion into ZnCr-layered double hydroxide (LDH) for pyrophosphate removal from industrial wastewater.

This work incorporated technological values into ZnCr-layered double hydroxide (LDH), synthesized from unused resources, for removal of pyrophosphate (PP) in electroplating wastewater. To adopt a resource recovery for the remediation of the aquatic environment, the ZnCr-LDH was fabricated by co-precipitation from concentrated metals of plating waste that remained as industrial by-products from metal finishing processes. To examine its applicability for water treatment, batch experiments were conducted at optimum M/M, pH, reaction time, and temperature.

Antioxidants Associated With Oncogenic Human Papillomavirus Infection in Women.

Background: Human papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed the onset of HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The association between antioxidants and oncogenic HPV remains unclear.

Nano zero-valent iron: A pH buffer, electron donor and activator for chain elongation.

Chain elongation produce medium chain carboxylates, which are important precursors to many pharmaceuticals, antimicrobials and biofuels. Results in the presented investigations show that the supply of nano zero-valent iron (NZVI) can enhance caproate production. The highest caproate concentration achieved amounted to 27.

Arsenic removal in aqueous solutions using FeS.

This study tested the technical feasibility of pyrite and/or persulfate oxidation system for arsenic (As) removal from aqueous solutions. The effects of persulfate on As removal by the pyrite in the integrated treatment were also investigated. Prior to the persulfate addition into the reaction system, the physico-chemical interactions between As and the pyrite alone in aqueous solutions were explored in batch studies.

[Analysis of five children with acquired thrombotic thrombocytopenic purpura].

To investigate the clinical characteristics, treatment and prognosis of children with acquired thrombotic thrombocytopenic purpura (TTP). The clinical manifestations, laboratory examination, treatment and prognosis of 5 children with acquired TTP hospitalized in Beijing Children's Hospital, Capital Medical University from January 2016 to July 2019 were analyzed retrospectively. There were 5 children with acquired TTP including 2 males and 3 females, with the onset age of 8.

Shexiang Tongxin dropping pill protects against sodium laurate-induced coronary microcirculatory dysfunction in rats.

Objective: To investigate the protective effects of Shexiang Tongxin dropping pill (, STDP) in a rat model of coronary microcirculatory dysfunction (CMD).

Methods: Sprague-Dawley rats were allocated randomly into four groups: sham, CMD model, STDP, and nicorandil. After 4 weeks of treatment, CMD was induced by injection of sodium laurate (0.