Publications by authors named "G-F Kuang"
Article Synopsis
- Fanzor (Fz) is an endonuclease guided by ωRNA, prevalent in eukaryotes, with significant potential for gene editing.
- The study reveals that Fzs from three different organisms share a common interface for interacting with ωRNA, despite differences in RNA length among species, and also details their DNA recognition and unwinding abilities.
- The analysis highlights how structural changes in Fz enable it to bind double-stranded DNA, illustrating the mechanism of its nuclease activity and providing a basis for future engineering of this system.
The article "Inhibition effects of acridone on the growth of breast cancer cells in vivo", by Y.-F. Xia, H.
View Article and Find Full Text PDFGlucocorticoid-induced tumor necrosis factor receptor (GITR) is a co-stimulatory receptor and an important target for cancer immunotherapy. We herein present a potent FcγR-independent GITR agonist IBI37G5 that can effectively activate effector T cells and synergize with anti-programmed death 1 (PD1) antibody to eradicate established tumors. IBI37G5 depends on both antibody bivalency and GITR homo-dimerization for efficient receptor cross-linking.
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