Effect of Strain on the Photocatalytic Reaction of Graphitic Carbon Nitride: Insight from Single-Molecule Localization Microscopy.

Strain engineering in two-dimensional nanomaterials holds significant potential for modulating the lattice and band structure, particularly through localized strain, which enables modulation at specific regions. Despite the remarkable effects of local strain, the relationships among local strain, spatial correlation of photogenerated charge carriers, and photocatalytic performance remain elusive. The current study coupled single-molecule localization microscopy with coordinate-based colocalization (CBC) analysis to explain these relationships.

Characterization of a phage 4FS1 and its depolymerase.

The significant economic losses caused by in donkey husbandry have increased interest in exploring the potential of phages and their enzymes as control strategies. In this study, a phage, designated 4FS1, was isolated from sewage at a donkey farm. Transmission electron microscopy (TEM) revealed a typical icosahedral head and a long, non-contractile tail.

Green preparation of nitrogen vacancies enriched g-CN for efficient photocatalytic reduction of CO and Cr(VI).

Introducing vacancies has emerged as one of the valid strategies to modulate the photocatalytic performance of graphitic carbon nitride (g-CN). Introduction of nitrogen vacancies into g-CN can create defect energy levels and trap electrons, consequently accelerating the separation of e/h pairs and effectively boosting photocatalytic activity. Nitrogen vacancies can also serve as adsorption active sites, enhancing the adsorption capacity of the catalyst towards the target molecule (CO).

Graphite Phase Carbon Nitride Nanosheets-Based Fluorescent Sensors for Analysis and Detection.

Fluorescent sensors reflect information such as the concentration or content of the analysis by interacting with a specific recognition group to change the signal of the fluorophore. It has attracted much attention because of its advantages of high sensitivity, fast detection speed and low cost, and it has become an effective alternative to traditional detection methods. Graphitic phase carbon nitride nanosheets (g-CNNs) are a class of carbon-based fluorescent nanomaterials derived from bulk graphite phase carbon nitride (g-CN), which have attracted much attention from scholars because of their advantages of low cost, simple fabrication, high quantum yield, strong stability and nontoxicity.

Redox Oscillation-Driven Production of Reactive Oxygen Species from Black Carbon.

Wildfire and stubble burning release substantial amounts of black carbon (BC) into natural environments that experience frequent redox oscillations, such as wetlands and farmlands. Here, we report that redox oscillations can effectively drive ROS production from BC. Following sequential microbial reduction and air exposure, 6.

The cumulative effect of compound heterozygous variants in TRPV3 caused Olmsted syndrome.

Background: Olmsted syndrome (OS) is a rare genodermatosis predominantly inherited in an autosomal dominant manner, typically arising from gain-of-function (GOF) variants in the transient receptor potential channel vanilloid 3 (TRPV3) gene.

Objective: This study aims to investigate potential mechanisms underlying OS in two cases presenting with an autosomal recessive inheritance pattern.

Methods: Next-generation sequencing panel was employed to identify TRPV3 variants.

sp. nov., a novel actinobacterium isolated from the gill of the leopard coral grouper ().

A novel actinomycete, designated strain ZYX-F-249, was isolated from the gill of a leopard coral grouper in Yongxing Island, Hainan Province, China. Based on 16S rRNA gene sequence analysis, strain ZYX-F-249 belonged to the genus , with high similarities to ATCC 12950 (98.7 %), 211020 (98.

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging.

To systematically characterize the loss of tissue integrity and organ dysfunction resulting from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male mice during aging. We showed that senescence-sensitive spots (SSSs) colocalized with elevated entropy in organizational structure and that the aggregation of immunoglobulin-expressing cells is a characteristic feature of the microenvironment surrounding SSSs. Immunoglobulin G (IgG) accumulated across the aged tissues in both male and female mice, and a similar phenomenon was observed in human tissues, suggesting the potential of the abnormal elevation of immunoglobulins as an evolutionarily conserved feature in aging.

A-to-G/C/T and C-to-T/G/A dual-function base editor for creating multi-nucleotide variants.

Multi-nucleotide variants (MNVs) are critical genetic variants associated with various genetic diseases. However, tools for precisely installing MNVs are limited. In this study, we present the development of a dual-base editor, BDBE, by integrating TadA-dual and engineered human N-methylpurine DNA glycosylase (eMPG) into nCas9 (D10A).

[Analysis of RhC Antigen Weak Expression Combined with Mimicking Autoanti-Ce and Homologous Anti-Jkb Causing Mismatch].

Objective: To investigate the reasons for the weak expression of gene in a patient whose mimicking anti-Ce combined with anti-Jkb caused cross-matching non-combination.

Methods: ABO, Rh, and Kidd blood group antigens were identified by test tube method and capillary centrifugation. Antibody screening and antibody specificity identification were performed using saline, polybrene and antiglobulin in tri-media association with multispectral cells.

Phosphatidylserine-blocking nanoparticles inhibit thrombosis without increased bleeding in mice.

Background: Phosphatidylserine (PS) is a procoagulant phospholipid enriched on surfaces of activated vascular cells including platelets, endothelium, monocytes, and microvesicles. As a molecular driver of thrombosis accessible to drug blockade, PS is an attractive pharmacologic target for modulating thrombogenesis, with potentially reduced bleeding risk compared to anticoagulant and antiplatelet therapies.

Objectives: Test antithrombotic capabilities of a liposomal formulation, Zn-dipicolylamine cyanine-3[22,22]/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (molar ratio, 3:97), designated as DPAL, which we previously described binds selectively to PS-enriched cell surfaces, compared with effects on bleeding, in mouse models.

The increasing rate of net carbon uptake in Eurasia has been declining since the early 2000s.

The analysis of terrestrial ecosystem carbon dynamics, based on scarce carbon flux observations or carbon flux products simulated by reanalysis meteorological data, has great uncertainties. A more accurate understanding of carbon dynamics in Eurasia was achieved by using a carbon flux dataset (CFD) from meteorological stations with quasi-observational characteristics. The growth of net carbon uptake of ecosystems over Eurasia has been decreasing since the early 2000s.

Codon Bias of the Gene and Transcription Factor EHF in Multiple Species.

Milk production is an essential economic trait in cattle, and understanding the genetic regulation of this trait can enhance breeding strategies. The discoidin domain receptor 1 () gene has been identified as a key candidate gene that influences milk production, and ETS homologous factor (EHF) is recognized as a critical transcription factor that regulates expression. Codon usage bias, which affects gene expression and protein function, has not been fully explored in cattle.

Enhanced-electrochemiluminescence biosensor for detecting miRNA-21 based on a CuO-mediated click reaction and catalytic hairpin self-assembly.

MicroRNAs (miRNAs) are closely associated with cancer and have been considered cancer biomarkers. Herein, we propose an electrochemiluminescence (ECL) biosensor for detecting miRNA-21 based on target-induced catalytic hairpin self-assembly (CHA) and CuO-mediated azide-alkyne cycloaddition. Two hairpin DNAs were employed: one was immobilized on magnetic beads (HP2) and another was labeled with CuO (HP1-CuO).

Oxygen-Doped Porous Ultrathin Graphitic Carbon Nitride Nanosheets for Photocatalytic Hydrogen Evolution and Rhodamine B Degradation.

Graphite phase carbon nitride (g-CN) is a highly promising metal-free photocatalyst, but its low activity, due to limited quantum efficiency and small specific surface area, restricts its practical application. While exfoliating bulk crystals into porous thin-layer nanosheets and incorporating dopants have been shown to improve photocatalytic efficiency, these methods are typically complex, time-consuming, and costly processes. In this study, we developed a simple approach to synthesize oxygen-doped porous g-CN (OCN) nanosheets.

Genotype-phenotype correlation and founder effect analysis in southeast Chinese patients with sialidosis type I.

Background: Sialidosis type 1 (ST-1) is a rare autosomal recessive disorder caused by mutation in the NEU1 gene. However, limited reports on ST-1 patients in the Chinese mainland are available.

Methods: This study reported the genetic and clinical characteristics of 10 ST-1 patients from southeastern China.

Bioderived carbon aerogels loaded with g-CN and their high Efficacy removing volatile organic compounds (VOCs).

Indoor air pollution, predominantly caused by volatile organic compounds (VOCs), poses significant health hazards when concentrations surpass critical thresholds. Using waste corn straw as carbon source and urea as nitrogen source, straw derived carbon aerogel (CAGH) loaded with g-CN was successfully prepared by hydrothermal and water-assisted calcination. Following water-assisted regulation, g-CN on CAGH exhibited a mixed structure comprising honeycomb and two-dimensional filaments, while the growth of g-CN was uniformly distributed on carbon aerogel in a line-surface combination fashion.

Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites.

Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen, requiring >100-fold higher doses for tumor induction, which may be explained by toxicokinetic differences between humans and mice. The human ATP-binding cassette subfamily C (ABCC) transporter hABCC4 mediates the cellular efflux of a diverse array of metabolites, including the glutathione (GSH) conjugate of the highly toxic monomethylarsonous acid (MMA), monomethylarsenic diglutathione [MMA(GS)], and the major human urinary arsenic metabolite dimethylarsinic acid (DMA).

Insight into the unique role of silver single-atom in atomic-thickness ZnInS/g-CN Van der Waals heterojunction for photocatalytic hydrogen evolution.

The construction of ultra-close 2D atomic-thickness Van der Waals heterojunctions with high-speed charge transfer still faces challenges. Here, we synthesized single-layer ZnInS and g-CN, and introduced silver single atoms to regulate Van der Waals heterojunctions at the atomic level to optimize charge transfer and catalytic activity. At the atomic scale, the impact of detailed structural differences between the two characteristic surfaces of ZnInS ([Zn-S] and [In-S]) on catalytic performance has been first proposed.