Publications by authors named "G-A Rizzi"
Article Synopsis
- Glioblastoma (GBM) is a very dangerous brain tumor, and there isn't a good way to find or treat it early on.
- Researchers have created special fluorescent probes using curcumin that can specifically attach to a certain enzyme (ALDH1A3) found in glioma stem cells, helping to identify these tumor cells.
- These probes work well in recognizing GBM cells both in lab tests and in living organisms, which could help doctors see where to cut during brain surgery.
This study examined the pharmacologic characterization of CHF6001 [(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide], a novel phosphodiesterase (PDE)4 inhibitor designed for treating pulmonary inflammatory diseases via inhaled administration. CHF6001 was 7- and 923-fold more potent than roflumilast and cilomilast, respectively, in inhibiting PDE4 enzymatic activity (IC50 = 0.026 ± 0.
View Article and Find Full Text PDFThe effect of pH and temperature on kinetic and thermodynamic parameters for the binding of the bovine basic pancreatic trypsin inhibitor (Kunitz inhibitor; BPTI) as well as bovine and porcine pancreatic secretory trypsin inhibitor (Kazal inhibitor; bovine and porcine PSTI, respectively) to human cathepsin G (EC 3.4.21.
View Article and Find Full Text PDF