Publications by authors named "G de Villareal"
Article Synopsis
- Peripheral intravenous catheter (PIVC) insertion is a common procedure in hospitals, but data from Latin America is limited, leading to this study that examined guidelines, issues, and practices across five countries.
- In 2019, researchers assessed 9,620 PIVCs in hospitals from Argentina, Brazil, Chile, Colombia, and Mexico, discovering inadequate replacement protocols and non-adherence to sterile dressing standards.
- The study found that most PIVCs were used for medications or fluids, with various complications noted, highlighting the need for improved clinical guidelines and training in multiple languages to enhance safety and quality in PIVC management.
Modeling non-clinical and clinical drug tests in Gaucher disease.
Annu Int Conf IEEE Eng Med Biol Soc
August 2016
There is need for modeling biological systems to accelerate drug pipelines for treating metabolic diseases. The eliglustat treatment for Gaucher disease is approved by the FDA with a companion genomic test. The Transcriptome-To-Metabolome™ biosimulation technology was used to model, in silico, a standard non-clinical eliglustat test with an in vitro canine kidney cell system over-expressing a human gene; and a clinical test using human fibroblasts from control and Gaucher disease subjects.
View Article and Find Full Text PDFThe purpose of this review is to provide Latin America's and the region's healthcare professionals with an overview of the current situation related to Zika virus (ZIKAV), and at the same time, to provide relevant clinical and molecular knowledge against this emerging problem. We expect to have a positive impact in diagnostic, surveillance and treatment of this viral disease, specially in those endemic communities, as part of a collective effort against the virus. This review will be distributed as hard-copy and online as a public health and epidemiological initiative.
View Article and Find Full Text PDFBiomarkers from biosimulations: Transcriptome-To-Reactome™ Technology for individualized medicine.
Annu Int Conf IEEE Eng Med Biol Soc
October 2015
We validated a model of the TGF-β signaling pathway using reactions from Reactome. Using a patentpending technique, gene expression profiles from individual patients are used to determine model parameters. Gene expression profiles from 45 women, normal, or benign tumor and malignant breast cancer were used as training and validating sets for assessing clinical sensitivity and specificity.
View Article and Find Full Text PDFBackground: The presence of femoroacetabular impingement (FAI) after a slipped capital femoral epiphysis is thought to predispose the subsequent development of osteoarthritis (OA); however, there is a lack of evidence to support this hypothesis.
Methods: One hundred twenty-one patients with stable slipped capital femoral epiphysis treated with in situ fixation were reviewed at a minimum of 20-year follow-up; the presence of a pistol grip deformity and FAI was determined. The Harris Hip Score (HHS) was used to measure clinical outcome, and the Tönnis grade for qualifying the presence of OA was determined.